A two-stage model of dendritic integration in CA1 pyramidal neurons (Katz et al. 2009)


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Accession:127351
"... In a two-stage integration model, inputs contribute directly to dendritic spikes, and outputs from multiple branches sum in the axon. ... We used serial-section electron microscopy to reconstruct individual apical oblique dendritic branches of CA1 pyramidal neurons and observe a synapse distribution consistent with the two-stage integration model. Computational modeling suggests that the observed synapse distribution enhances the contribution of each dendritic branch to neuronal output."
Reference:
1 . Katz Y, Menon V, Nicholson DA, Geinisman Y, Kath WL, Spruston N (2009) Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons. Neuron 63:171-7 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON (web link to model);
Model Concept(s): Synaptic Integration;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; I Na,t; I A; I K;
(located via links below)

Katz Y, Menon V, Nicholson DA, Geinisman Y, Kath WL, Spruston N (2009) Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons. Neuron 63:171-7[PubMed]

References and models cited by this paper

References and models that cite this paper

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