Rapid desynchronization of an electrically coupled Golgi cell network (Vervaeke et al. 2010)


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Accession:127996
Electrical synapses between interneurons contribute to synchronized firing and network oscillations in the brain. However, little is known about how such networks respond to excitatory synaptic input. In addition to detailed electrophysiological recordings and histological investigations of electrically coupled Golgi cells in the cerebellum, a detailed network model of these cells was created. The cell models are based on reconstructed Golgi cell morphologies and the active conductances are taken from an earlier abstract Golgi cell model (Solinas et al 2007, accession no. 112685). Our results show that gap junction coupling can sometimes be inhibitory and either promote network synchronization or trigger rapid network desynchronization depending on the synaptic input. The model is available as a neuroConstruct project and can executable scripts can be generated for the NEURON simulator.
Reference:
1 . Vervaeke K, Lorincz A, Gleeson P, Farinella M, Nusser Z, Silver RA (2010) Rapid Desynchronization of an Electrically Coupled Interneuron Network with Sparse Excitatory Synaptic Input. Neuron 67:435-451 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum golgi cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I K; I M; I K,Ca; I Calcium; I Potassium; I_AHP;
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: neuroConstruct (web link to model); NeuroML (web link to model);
Model Concept(s): Ion Channel Kinetics; Oscillations; Synchronization; Detailed Neuronal Models;
Implementer(s): Gleeson, Padraig [p.gleeson at ucl.ac.uk]; Vervaeke, Koen [k.vervaeke at ucl.ac.uk];
Search NeuronDB for information about:  GabaA; AMPA; I Na,p; I Na,t; I L high threshold; I A; I K; I M; I K,Ca; I Calcium; I Potassium; I_AHP; Gaba; Glutamate;
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