Short term plasticity at the cerebellar granule cell (Nieus et al. 2006)

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The model reproduces short term plasticity of the mossy fibre to granule cell synapse. To reproduce synaptic currents recorded in experiments, a model of presynaptic release was used to determine the concentration of glutamate in the synaptic cleft that ultimately determined a synaptic response. The parameters of facilitation and depression were determined deconvolving AMPA EPSCs.
1 . Nieus T, Sola E, Mapelli J, Saftenku E, Rossi P, D'Angelo E (2006) LTP regulates burst initiation and frequency at mossy fiber-granule cell synapses of rat cerebellum: experimental observations and theoretical predictions. J Neurophysiol 95:686-99 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule cell;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Short-term Synaptic Plasticity;
Implementer(s): Nieus, Thierry [thierry.nieus at];
Search NeuronDB for information about:  Cerebellum interneuron granule cell; AMPA; NMDA; Glutamate;
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