Synthesis of spatial tuning functions from theta cell spike trains (Welday et al., 2011)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:129067
A single compartment model reproduces the firing rate maps of place, grid, and boundary cells by receiving inhibitory inputs from theta cells. The theta cell spike trains are modulated by the rat's movement velocity in such a way that phase interference among their burst pattern creates spatial envelope function which simulate the firing rate maps.
Reference:
1 . Welday AC, Shlifer IG, Bloom ML, Zhang K, Blair HT (2011) Cosine directional tuning of theta cell burst frequencies: evidence for spatial coding by oscillatory interference. J Neurosci 31:16157-76 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Entorhinal cortex stellate cell;
Channel(s): I Na,p;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Synchronization; Envelope synthesis; Grid cell; Place cell/field;
Implementer(s): Blair, Hugh T.;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; GabaA; AMPA; I Na,p; Gaba; Glutamate;
COMMENT
-----------------------------------------------------------------------------
from ModelDB:

Uebachs M, Opitz T, Royeck M, Dickhof G, Horstmann MT, Isom LL, Beck H (2010) 
Efficacy Loss of the Anticonvulsant Carbamazepine in Mice Lacking Sodium Channel 
beta Subunits via Paradoxical Effects on Persistent Sodium Currents. J Neurosci 30:8489-501 
-----------------------------------------------------------------------------
ENDCOMMENT

TITLE nap

NEURON {
	SUFFIX nap
	USEION na READ ena WRITE ina
	RANGE  gbar, thegna, sh, scalerate
	GLOBAL minf, mtau 
	:, hinf, mtau, htau
}

PARAMETER {
	gbar = .0052085   	(mho/cm2)
	sh = 0  (mV)
	eNa = 55 	(mV)
	scalerate = 1	(ms)	
	ena		(mV)            
	celsius (degC)
	v 		(mV)
}


UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(pS) = (picosiemens)
	(um) = (micron)
} 

ASSIGNED {
	ina 		(mA/cm2)
	thegna		(mho/cm2)
	minf 	
	mtau (ms)
}
 

STATE { m }

UNITSOFF

BREAKPOINT {
    SOLVE states METHOD cnexp
	        		
	thegna =gbar*m       
	ina = thegna * (v - eNa)
	} 

INITIAL {
	mtau = scalerate
	minf = (1/(1+exp(-(v+52.3-sh)/6.8)))      	
	m=minf  
	
}

DERIVATIVE states {   
    
	mtau = scalerate
	minf = (1/(1+exp(-(v+52.3-sh)/6.8))) 	         	
	m' = (minf-m)/mtau
}



UNITSON

Loading data, please wait...