Action potential reconstitution from measured current waveforms (Alle et al. 2009)

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Accession:135838
This NEURON code reconstitutes action potentials in a model of a hippocampal mossy fiber from experimentally measured sodium, potassium and calcium current waveforms as described in Alle et al. (2009).
Reference:
1 . Alle H, Roth A, Geiger JR (2009) Energy-efficient action potentials in hippocampal mossy fibers. Science 325:1405-8 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Dentate gyrus granule GLU cell;
Channel(s): I Na,t; I K; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Roth, Arnd ; Alle, Henrik;
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; I Na,t; I K; I Calcium;
TITLE GCa.mod

COMMENT

GCa.mod
conductance read from a file, starting after vthreshold is exceeded

ENDCOMMENT

NEURON {
	SUFFIX GCa
	USEION ca READ eca WRITE ica
	RANGE vthreshold, gcabar, gt, initflag, del
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(S) = (siemens)
}

PARAMETER {
	vthreshold  (mV)
	gcabar (S/cm2)
}

ASSIGNED {
	v (mV)
	eca (mV)
	ica (mA/cm2)
	initflag (1)
	del (ms)
	gt (1)
}

INITIAL {
	initflag = 0
	del = 0
	gt = 0
}

BREAKPOINT {
	SOLVE check METHOD after_cvode
	at_time(del)

	if (initflag) {
		gt = stepforce(t - del, "gCa.dat")
		ica = gcabar*gt*(v - eca)
	}else{
		gt = 0
		ica = 0
	}
}

PROCEDURE check() {
	if (initflag == 0 && v > vthreshold) {
		initflag = 1
		del = t
	}
}

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