AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)

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Accession:135839
This simple axon-soma model explained how the rapid rising phase in the somatic spike is derived from the propagated axon initiated spike, and how the somatic spike threshold variance is affected by spike propagation.
Reference:
1 . McCormick DA, Shu Y, Yu Y (2007) Hodgkin and Huxley model still standing? Nature 445:E1-E2 [PubMed]
2 . Yu Y, Shu Y, McCormick DA (2008) Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. J Neurosci 28:7260-72 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s): GabaA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Detailed Neuronal Models;
Implementer(s):
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell; GabaA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I_AHP;
/
McCormickEtAl2007YuEtAl2008
readme.txt
ca.mod *
cad.mod *
caL3d.mod *
capump.mod
gabaa5.mod *
Gfluct.mod *
ia.mod *
iahp.mod *
iahp2.mod *
ih.mod
im.mod *
kca.mod *
km.mod *
kv.mod *
na.mod *
NMDA_Mg.mod *
nmda5.mod *
release.mod *
for_plot_spike.m
mosinit.hoc
neuron_soma.dat
Rapid_rising_somatic_spike_soma_axon.hoc
                            
These model files were for the paper:

Yu Y.G., Shu Y., Duque A., Haider B., and McCormick D.A.  
Cortical Action Potential Back-propagation Explains Spike Threshold
Variability and Rapid-Onset Kinetics.
Journal of Neuroscience, 28: 7260-7272, (2008).

and also

McCormick D.A., Shu Y., and Yu Y.G.     
Neurophysiology: Hodgkin and Huxley model - still standing?
Nature. 445: E1-E2, (2007).  

This simple axon-soma model explained how the rapid rising phase in
somatic spike is derived from propagated axon initiated spike.

Creates a single cell containing a dendrite, soma, an axon with 60
micrometer and a axon bleb to investigate generation of spike kink at
soma. As observed in experiment, spikes are usually initiated at the
axon site 40~70 micrometer away from soma.  There is a rapid rising
phase in somatic spike, due to the initial segment traveling spike.

After running the code, there is an output data file called
'neuron_soma.dat' Use the matlab code for_plot_spike.m to plot the
somatic spike and axon spike.

These files were contributed by
Yuguo Yu
Yale University

yuguo.yu@yale.edu

20111026 updated release.mod to derivimplicit method.  See file for
more info.
20120409 updated cad.mod capump.mod to derivimplicit method which
should have been changed with above 20111026 update. See
http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592
20120515 Ted Carnevale supplied these updates which are THREADSAFE,
slightly cleaner code, and handle singularities correctly (ca.mod,
km.mod, and kv.mod didn't).

McCormick DA, Shu Y, Yu Y (2007) Hodgkin and Huxley model still standing? Nature 445:E1-E2[PubMed]

References and models cited by this paper

References and models that cite this paper

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   [2 reconstructed morphologies on NeuroMorpho.Org]
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Naundorf B, Wolf F, Volgushev M (2006) Unique features of action potential initiation in cortical neurons. Nature 440:1060-3 [PubMed]

Palmer LM, Stuart GJ (2006) Site of action potential initiation in layer 5 pyramidal neurons. J Neurosci 26:1854-63 [PubMed]

Pare D, Shink E, Gaudreau H, Destexhe A, Lang EJ (1998) Impact of spontaneous synaptic activity on the resting properties of cat neocortical pyramidal neurons In vivo. J Neurophysiol 79:1450-60 [Journal] [PubMed]

Shu Y, Duque A, Yu Y, Haider B, McCormick DA (2007) Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. J Neurophysiol 97:746-60 [Journal] [PubMed]

   Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007) [Model]

Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick DA (2003) Barrages of synaptic activity control the gain and sensitivity of cortical neurons. J Neurosci 23:10388-401 [PubMed]

Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA (2006) Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 441:761-5 [Journal] [PubMed]

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   Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009) [Model]

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Oz P, Huang M, Wolf F (2015) Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment. J Comput Neurosci 39:63-75 [Journal] [PubMed]

   MCCAIS model (multicompartmental cooperative AIS) (Öz et al 2015) [Model]

Platkiewicz J, Brette R (2010) A threshold equation for action potential initiation. PLoS Comput Biol 6:e1000850 [Journal] [PubMed]

   A threshold equation for action potential initiation (Platkiewicz & Brette 2010) [Model]

Platkiewicz J, Brette R (2011) Impact of fast sodium channel inactivation on spike threshold dynamics and synaptic integration. PLoS Comput Biol 7:e1001129-78 [Journal] [PubMed]

   Impact of fast Na channel inact. on AP threshold & synaptic integration (Platkiewicz & Brette 2011) [Model]

Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008) Role of Axonal NaV1.6 Sodium Channels in Action Potential Initiation of CA1 Pyramidal Neurons. J Neurophysiol [Journal] [PubMed]

   Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008) [Model]

Shu Y, Duque A, Yu Y, Haider B, McCormick DA (2007) Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. J Neurophysiol 97:746-60 [Journal] [PubMed]

   Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007) [Model]

Shu Y, Yu Y, Yang J, McCormick DA (2007) Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proc Natl Acad Sci U S A 104:11453-8 [Journal] [PubMed]

   Selective control of cortical axonal spikes by a slowly inactivating K+ current (Shu et al. 2007) [Model]

Yu Y, Shu Y, McCormick DA (2008) Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. J Neurosci 28:7260-72 [Journal] [PubMed]

   AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008) [Model]

(29 refs)

Yu Y, Shu Y, McCormick DA (2008) Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. J Neurosci 28:7260-72[PubMed]

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Colbert CM, Pan E (2002) Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Nat Neurosci 5:533-8 [PubMed]

COOMBS JS, CURTIS DR, ECCLES JC (1957) The generation of impulses in motoneurones. J Physiol 139:232-49 [PubMed]

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Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick DA (2003) Barrages of synaptic activity control the gain and sensitivity of cortical neurons. J Neurosci 23:10388-401 [PubMed]

Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA (2006) Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature 441:761-5 [Journal] [PubMed]

   Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007) [Model]

Shu Y, Yu Y, Yang J, McCormick DA (2007) Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proc Natl Acad Sci U S A 104:11453-8 [Journal] [PubMed]

   Selective control of cortical axonal spikes by a slowly inactivating K+ current (Shu et al. 2007) [Model]

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   [4 reconstructed morphologies on NeuroMorpho.Org]
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Hu W, Tian C, Li T, Yang M, Hou H, Shu Y (2009) Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nat Neurosci 12:996-1002 [Journal] [PubMed]

   Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009) [Model]

Ju H, Hines ML, Yu Y (2016) Cable energy function of cortical axons. Sci Rep 6:29686 [Journal] [PubMed]

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Oz P, Huang M, Wolf F (2015) Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment. J Comput Neurosci 39:63-75 [Journal] [PubMed]

   MCCAIS model (multicompartmental cooperative AIS) (Öz et al 2015) [Model]

Platkiewicz J, Brette R (2010) A threshold equation for action potential initiation. PLoS Comput Biol 6:e1000850 [Journal] [PubMed]

   A threshold equation for action potential initiation (Platkiewicz & Brette 2010) [Model]

Platkiewicz J, Brette R (2011) Impact of fast sodium channel inactivation on spike threshold dynamics and synaptic integration. PLoS Comput Biol 7:e1001129-78 [Journal] [PubMed]

   Impact of fast Na channel inact. on AP threshold & synaptic integration (Platkiewicz & Brette 2011) [Model]

(59 refs)