Selective control of cortical axonal spikes by a slowly inactivating K+ current (Shu et al. 2007)

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Accession:135898
We discovered a low-threshold, slowly inactivating K+ current, containing Kv1.2 alpha subunits, in axon initial segment, playing a key role in the modulation of spike threshold and spike duration as well as the spike timing in prefrontal cortex layer V pyramidal cell of ferrets and rats. A kd.mod file implements this D current and put it in the axonal model: Neuron_Dcurrent.hoc. Run the model to see the gradual modulation effect over seconds on spike shape.
Reference:
1 . Shu Y, Yu Y, Yang J, McCormick DA (2007) Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proc Natl Acad Sci U S A 104:11453-8 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic cell; Neocortex V1 L2/6 pyramidal intratelencephalic cell;
Channel(s): I Na,t; I K; I h; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s): Kv1.2 KCNA2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Action Potentials;
Implementer(s):
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic cell; Neocortex V1 L2/6 pyramidal intratelencephalic cell; I Na,t; I K; I h; I Potassium;
These files contain the model for the paper:

Shu Y, Yu YG, Yang, J. and McCormick DA Selective control of cortical
axonal action potentials by a slowly inactivating K+ current.
Proceedings of the National Academy of Sciences (PNAS) 27:
11453-11458, (2007).

A simple model of a soma and axon was constructed by using Neuron.

The soma had a diameter and length of 20 mm (1 compartment) and
contained a leak conductance (reversal potential -70 mV) Rm = 30,000
Ohm/cm2 with membrane capacitance Cm = 0.75 mF/cm2.

The axon had a diameter of 1 mm and a length of between 20 and 200 mm,
with the later containing 10 compartments. In the axon, the leak
conductance Rm = 125,000 Ohm/cm2, and the membrane capacitance Cm =
0.75 mF/cm2. The axonal axial resistance was 150 W-cm.

Kv1.2 current exists in axon initial segment, which play important
roles in modulating spike duration and threshold of action potentials.

Running Neuron_Dcurrent.hoc, then analyze the output data file
soma_axon_id.dat to see D current effect on action potentials

These files were contributed by
Yuguo Yu 2007 Yale
yuguo.yu@yale.edu

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