CA1 stratum radiatum interneuron multicompartmental model (Katona et al. 2011)

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Accession:136176
The model examines dendritic NMDA-spike generation and propagation in the dendrites of CA1 stratum radiatum interneurons. It contains NMDA-channels in a clustered pattern on a dendrite and K-channels. The simulation shows the whole NMDA spike and the rising phase of the traces in separate windows.
Reference:
1 . Katona G, Kaszás A, Turi GF, Hájos N, Tamás G, Vizi ES, Rózsa B (2011) Roller Coaster Scanning reveals spontaneous triggering of dendritic spikes in CA1 interneurons. Proc Natl Acad Sci U S A 108:2148-53 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 stratum radiatum interneuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models;
Implementer(s): Rozsa, Balazs ;
Search NeuronDB for information about:  NMDA; I Na,t; I K;
COMMENT
//****************************//
// Created by Alon Polsky 	//
//    apmega@yahoo.com		//
//		2002			//
//****************************//
ENDCOMMENT

TITLE AMPA synapse

NEURON {
	POINT_PROCESS ampa_m
	NONSPECIFIC_CURRENT i
	RANGE tau,e,gw
	RANGE del,Tspike,Nspike
}

UNITS {
        (nS) = (nanosiemens)
        (nA) = (nanoamp)
        (mV) = (millivolt)
}

PARAMETER {
	tau=	5	: 1.1 	(ms)
	gw=0.01	(nS):weight of synapse
	e=0(mV)
	del=30	(ms)
	Tspike=10	(ms)
	Nspike=1
}

ASSIGNED {
	v (mV)
	i (nA)
}

STATE { g (nS) }

INITIAL { g= 0}

BREAKPOINT {
	LOCAL count

	SOLVE state METHOD cnexp

	FROM count=0 TO Nspike-1 {
		IF(at_time(count*Tspike+del)){
			state_discontinuity( g, g+ gw)
		}
	}

	i= (1e-3)*g* (v- e)
}

DERIVATIVE state {
	g'=-g/tau  

}


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