Effect of trp-like current on APs during exposure to sinusoidal voltage (Chen et al. 2010)

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Accession:137263
"... Previous work showed that magnetic electrical field-induced antinoceptive action is mediated by activation of capsaicin-sensitive sensory afferents. In this study, a modified Hodgkin-Huxley model, in which TRP-like current (I-TRP) was incorporated, was implemented to predict the firing behavior of action potentials (APs), as the model neuron was exposed to sinusoidal changes in externally-applied voltage. ... Our simulation results suggest that modulation of TRP-like channels functionally expressed in small-diameter peripheral sensory neurons should be an important mechanism through which it can contribute to the firing pattern of APs."
Reference:
1 . Chen BS, Lo YC, Liu YC, Wu SN (2010) Effects of transient receptor potential-like current on the firing pattern of action potentials in the Hodgkin-Huxley neuron during exposure to sinusoidal external voltage Chinese Journal of Physiology 53(6):423-429 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Squid axon;
Channel(s): I trp;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Simplified Models; Tutorial/Teaching; Action Potentials;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw];
Search NeuronDB for information about:  I trp;
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V_trp
readme.html
CJP099026.pdf
HH-Vext.ode
screenshot.jpg
                            
# HH-Vext.ode: an XppAut file for the Hodgkin-Huxley equations
# Ref: Chen et al., Chinese J Physiol 2010, 54 (6), 423-429.
# + strength of external electrical field
# + trp channel
# time in msec, voltage in mV and frequency in Hz

# initial conditions
init v=-71, m=0.038, h=0.69, n=0.159

# the parameters
param vext=8, iapp=0, freq=0.3
param gna=120
param gk=36, gl=0.3, gtrp=0.03, cm=1
number vna=50, vk=-80, vtrp=0, vl=-49

# time constants and steady state functions for gating variables
am(v)=0.1*(v+40)/(1-exp(-(v+40)/10))
bm(v)=4*exp(-(v+65)/18)
ah(v)=0.07*exp(-(v+65)/20)
bh(v)=1/( 1+ exp(-(v+35)/10) )
an(v)=0.01*(v+55)/(1-exp(-(V + 55)/10))
bn(v)=0.125*exp(-(V+65)/80)

vex(t)=vext*(sin(2*pi*(freq/1000)*t))
ik=gk*n^4*(v+vex(t)-vk)
ina=gna*m^3*h*(v+vex(t)-vna)
il=gl*(v+vex(t)-vl)
itrp=gtrp*(v+vex(t)-vtrp)

# the equations
v'=(-ik-ina-il-itrp+iapp)/cm
m'=(am(v)*(1-m)-bm(v)*m)
n'=(an(v)*(1-n)-bn(v)*n)
h'=(ah(v)*(1-h)-bh(v)*h)

aux vex=vex(t)
aux itrp=itrp

# set xpp parameters
@ total=10000, xp=t, yp=v, xlo=0, xhi=10000, ylo=-90, yhi=50, bounds=10000000, dt=0.01
@ maxstor=10000000

done

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