CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)

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Accession:138205
NEURON files from the paper: A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. by M. Migliore, I. De Blasi, D. Tegolo, R. Migliore, Neural Networks,(2011), doi:10.1016/j.neunet.2011.01.001. Starting from the experimentally supported assumption on hippocampal neurons we explore an experimentally testable prediction at the single neuron level. The model shows how and to what extent a pathological hypofunction of a contextdependent distal input on a CA1 neuron can generate hallucinations by altering the normal recall of objects on which the neuron has been previously tuned. The results suggest that a change in the context during the recall phase may cause an occasional but very significant change in the set of active dendrites used for features recognition, leading to a distorted perception of objects.
Reference:
1 . Migliore M, De Blasi I, Tegolo D, Migliore R (2011) A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. Neural Netw 24:552-9 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I h; I Potassium;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Coincidence Detection; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Schizophrenia; Hallucinations;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Na,t; I A; I K; I h; I Potassium; Glutamate;
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Schizophr
readme.txt
distr.mod *
Gfluct.mod
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3n.mod *
naxn.mod *
netstims.mod *
average.hoc
c033-all-seeds.txt
condu.txt
fixnseg.hoc *
geo9068802.hoc
mosinit.hoc
schizopr.ses
sim_9068802-test.hoc
                            
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 26  23  22  19  9  0.0256  0.12288  1 
 26  23  22  14  5  0.0256  0.12288  1 
 26  23  22  5  0  0.0256  0.12288  1 
 26  23  19  18  0  0.0256  0.12288  1 
 26  23  19  17  9  0.0256  0.12288  1 
 26  23  19  18  17  0.0256  0.12288  1 
 26  23  19  18  14  0.0256  0.12288  1 

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