Mechanisms of magnetic stimulation of central nervous system neurons (Pashut et al. 2011)

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Accession:138321
Transcranial magnetic stimulation (TMS) is a widely applied tool for probing cognitive function in humans and is one of the best tools for clinical treatments and interfering with cognitive tasks. Surprisingly, while TMS has been commercially available for decades, the cellular mechanisms underlying magnetic stimulation remain unclear. Here we investigate these mechanisms using compartmental modeling. We generated a numerical scheme allowing simulation of the physiological response to magnetic stimulation of neurons with arbitrary morphologies and active properties. Computational experiments using this scheme suggested that TMS affects neurons in the central nervous system (CNS) primarily by somatic stimulation.
Reference:
1 . Pashut T, Wolfus S, Friedman A, Lavidor M, Bar-Gad I, Yeshurun Y, Korngreen A (2011) Mechanisms of magnetic stimulation of central nervous system neurons. PLoS Comput Biol 7:e1002022 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic cell; Squid axon;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Action Potential Initiation; Magnetic stimulation;
Implementer(s): Korngreen, Alon [alon.korngreen at gmail.com]; Pashut, Tamar [tamar.pashut at gmail.com];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic cell;
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pashut2011
TwoDimensions
Neuron
cells
cad2.mod *
child.mod *
childa.mod *
epsp.mod *
it2.mod *
kaprox.mod *
kca.mod *
km.mod *
kv.mod *
na.mod *
SlowCa.mod *
xtra.mod *
alon.ses
BACModel.hoc
BACModel_mag.hoc
Display.ses *
magstim.hoc
                            
 COMMENT
 iterator for traversing all the descendants of the currently accessed section
 
 section subtree_traverse("statement")
 
 executes statement for section and every descendant of section.
 Just before the statement is executed the currently accessed section is set.
 
 ENDCOMMENT
 
 NEURON {
 	SUFFIX nothing
 }
 
 VERBATIM
 static subtree(sec, sym) Section* sec; Symbol* sym; {
 	Section* child;
 
 	nrn_pushsec(sec);	/* move these three (sec becomes child) */
 	hoc_run_stmt(sym);	/* into the loop to do only the first level */
 	nrn_popsec();
 
 	for (child = sec->child; child; child = child->sibling) {
 		subtree(child, sym);
 	}
 }
 ENDVERBATIM
 
 PROCEDURE subtree_traverse_all() {
   VERBATIM
   {
 	Section* chk_access();
 	Symbol* hoc_parse_stmt();
 	Symlist* symlist = (Symlist*)0;
 	subtree(chk_access(), hoc_parse_stmt(gargstr(1), &symlist));
 	/* if following not executed (ie hoc error in statement),
 	   some memory will leak */
 	hoc_free_list(&symlist);
   }
   ENDVERBATIM
 }

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