Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)

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Accession:138379
"Coordination of neocortical oscillations has been hypothesized to underlie the "binding" essential to cognitive function. However, the mechanisms that generate neocortical oscillations in physiological frequency bands remain unknown. We hypothesized that interlaminar relations in neocortex would provide multiple intermediate loops that would play particular roles in generating oscillations, adding different dynamics to the network. We simulated networks from sensory neocortex using 9 columns of event-driven rule-based neurons wired according to anatomical data and driven with random white-noise synaptic inputs. ..."
Reference:
1 . Neymotin SA, Lee H, Park E, Fenton AA, Lytton WW (2011) Emergence of physiological oscillation frequencies in a computer model of neocortex. Front Comput Neurosci 5:19 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic cell; Neocortex V1 L2/6 pyramidal intratelencephalic cell; Neocortex V1 interneuron basket PV cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations; Synchronization; Laminar Connectivity;
Implementer(s): Lytton, William [bill.lytton at downstate.edu]; Neymotin, Sam [samn at neurosim.downstate.edu];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic cell; Neocortex V1 L2/6 pyramidal intratelencephalic cell; Neocortex V1 interneuron basket PV cell; GabaA; AMPA; NMDA; Gaba; Gaba; Glutamate;
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fdemo
readme.txt
intf6_.mod
misc.mod *
nstim.mod *
stats.mod *
vecst.mod
col.hoc
declist.hoc *
decmat.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
drline.hoc *
filtutils.hoc
finish_run.hoc
grvec.hoc *
init.hoc *
labels.hoc *
local.hoc *
misc.h
mosinit.hoc
network.hoc
nload.hoc
nqs.hoc *
nqsnet.hoc *
nrnoc.hoc *
params.hoc
python.hoc *
pywrap.hoc *
run.hoc
setup.hoc
simctrl.hoc *
spkts.hoc *
stats.hoc *
syncode.hoc *
xgetargs.hoc *
                            
// $Id: labels.hoc,v 1.95 2011/01/14 16:46:02 billl Exp $

load_file("declist.hoc")
// keep track of version number for future changes
// eg if (label_hoc_vers>88) rcsopen("labels.hoc",88) // go back to 88
labels_hoc_vers=find_num("$Id: labels.hoc,v 1.95 2011/01/14 16:46:02 billl Exp $","1\\."," ")
objref NCv,CODEv,DELv
objref PRIDv,POIDv,PRv,POv,DISTv,WT0v,WT1v // mo(1) will assign these
declare("ce",nil,"CTYP",new List(),"CPLA",new List(),"TPA",new List(),"nm",new List())
declare("STYP",new List(),"ncells",0,"ZTYP",new List(),"INCOL",new List())
declare("DEND",0,"SOMA",1,"AXON",2) // compartment codes - only 3 for now

//* utility functions
// plmin(val,var)
func plmin() { return $1 + $2*(2*u_rand() - 1) } 

//* cell types: 
// iex(), returns numeric index associated with a string or string object
func iex () { 
  if (argtype(1)==2) sprint(tstr,"x=%s",$s1) else sprint(tstr,"x=%s",$o1.s)
  execute(tstr) return x 
}
// ice(), returns whether cell is an inhib cell based on its name starting with I
func ice () { local x
  if (argtype(1)==2) return strm($s1,"^I")
  if (argtype(1)==0) x=$1 else if (argtype(1)==1) x=$o1.type 
  return strm(CTYP.o(x).s,"^I")
}
//* GetLyr - return layer of type
func GetLyr () { local x localobj st
  st=new String()
  if (argtype(1)==2) st.s=$s1 else if (argtype(1)==0) st.s=CTYP.o($1).s else {
    st.s=CTYP.o($o1.type).s }
  sscanf(st.s,"%*1s%d",&x)
  return x
}

proc printtype () { local i
  for (i=1;argtype(i)==0;i+=1) if ($i!=-1) printf("%s(%d) ",CTYP.o($i).s,$i)
  if (argtype(i)==2) printf("%s",$si) else print ""
}
proc celltype () { localobj st
  st=new String("\n")
  if (argtype(2)==2) st.s=$s2
  if (argtype(1)==0) printtype(ce.o($1).type,st.s) else printtype($o1.type,st.s) 
}

obfunc names2indices () { local x localobj lo,xo,st
  lo=new List() st=new String()
  split($s1,lo)
  for ltr(xo,lo,&x) { sprint(st.s,"%s=%d",xo.s,x) execute(st.s) }
  return lo
}

// at some point may want to divide up this list into cell type -- eg RS,IB and location
CTYP=names2indices("NU,SM,DP,SU,IN,TC,IRE,ITH,E6,I6,I6C,I6L,E5B,E5R,I5,I5L,E4,I4,I4L,E2,E2B,I2,I2Q,I2C,I2L,RS,IB,LTS,FS,ECA1,ICA1,ICA1L,EDG,IDG,IDGL,ECA3,ICA3,ICA3L,E3,I3,I3L")
CTYPi=CTYP.count  // number of cell types

// 1 cmp nrn, 2 cmp nrn, multi cmp nrn, intfire1, INTF, invlfire, nstim
for scase2(XO,"1-CMP","CMP1","2-CMP","CMP2","MULTI-CMP","MC","IntFire1","IF1","INTF","IF",\
          "INVLF","IFV","NStim","STM") { CPLA.append(XO)
  sprint(tstr,"%s=%d",XO.t,i1) execute(tstr) }
CPLAi=CPLA.count // count of cell templates

for scase2(XO,"REAL","RL","ARTC","AC","SOMA","SO","DEND","DN") {TPA.append(XO)}
TPAi=TPA.count

proc ae () { localobj xo
  STYP.remove_all
  for scase2(xo,"AMPA","AM","NMDA","NM","GABAA","GA","GABAB","GB",\
             "AMPA2","AM2","NMDA2","NM2","GABAA2","GA2","GABAB2","GB2",\
           "IClamp","IC","AMPA/NMDA","EX","GABAA/GABAB2","IX","Exp2Syn","E2Sy"){
    STYP.append(new String2(xo.t,xo.s)) // switch them around here
    sprint(tstr,"%s=%d",xo.t,i1)
    execute(tstr)
  }
  STYPi=STYP.count  // number of cell types
}
ae()

for scase(XO,"DG","CA3","CA1","SUB","PSUB","MEC","LEC") {
  sprint(tstr,"%s=%d",XO.s,i1) execute(tstr) ZTYP.append(new String(XO.s))
}

for scase2(XO,"RIGHT","RIT","INCOL","INC","LEFT","LFT") { INCOL.append(new String(XO.s))
  sprint(tstr,"%s=%d",XO.t,i1) execute(tstr) }
INCOLi=INCOL.count

//* IsLTS - return if type is LTS
func IsLTS () {
  return $1 == I2L || $1 == I4L || $1 == I5L || $1 == I6L 
}
//* IsBurst - return if type is intrinsically bursting
func IsBurst () {
  return $1 == E2B || $1 == E5B
}
//* IsFRB - return true if type is fast regular bursting
func IsFRB () {
  return $1 == E2B
}
//* IsRS - return true if type is regular spiking E cell
func IsRS () {
  return $1 == E2 || $1 == E4 || $1 == E5R || $1 == E6
}
//* IsFS - return true if type is fast spiking interneuron
func IsFS () {
  return $1 == I2 || $1 == I4 || $1 == I5 || $1 == I6 || $1 == ICA3 || $1 == IDG || $1 == ICA1
}

func isartcell () { return sfunc.is_point_process($o1) }


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