Emergence of physiological oscillation frequencies in neocortex simulations (Neymotin et al. 2011)

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Accession:138379
"Coordination of neocortical oscillations has been hypothesized to underlie the "binding" essential to cognitive function. However, the mechanisms that generate neocortical oscillations in physiological frequency bands remain unknown. We hypothesized that interlaminar relations in neocortex would provide multiple intermediate loops that would play particular roles in generating oscillations, adding different dynamics to the network. We simulated networks from sensory neocortex using 9 columns of event-driven rule-based neurons wired according to anatomical data and driven with random white-noise synaptic inputs. ..."
Reference:
1 . Neymotin SA, Lee H, Park E, Fenton AA, Lytton WW (2011) Emergence of physiological oscillation frequencies in a computer model of neocortex. Front Comput Neurosci 5:19-75 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell; Neocortex V1 interneuron basket PV cell; Neocortex fast spiking (FS) interneuron; Neocortex spiny stellate cell;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations; Synchronization; Laminar Connectivity;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu]; Neymotin, Sam [samn at neurosim.downstate.edu];
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell; Neocortex V1 interneuron basket PV cell; GabaA; AMPA; NMDA; Gaba; Gaba; Glutamate;
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fdemo
readme.txt
intf6_.mod
misc.mod *
nstim.mod *
stats.mod *
vecst.mod
col.hoc
declist.hoc *
decmat.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
drline.hoc *
filtutils.hoc
finish_run.hoc
grvec.hoc *
init.hoc *
labels.hoc *
local.hoc *
misc.h
mosinit.hoc
network.hoc
nload.hoc
nqs.hoc *
nqsnet.hoc *
nrnoc.hoc *
params.hoc
python.hoc *
pywrap.hoc *
run.hoc
setup.hoc
simctrl.hoc *
spkts.hoc *
stats.hoc *
syncode.hoc *
xgetargs.hoc *
                            
: $Id: nstim.mod,v 1.24 2006/04/03 19:18:18 billl Exp $

NEURON	{ 
  ARTIFICIAL_CELL NStim
  RANGE interval, number, start, end
  RANGE noise,type,id
}

PARAMETER {
  interval	= 10 (ms) <1e-9,1e9>: time between spikes (msec)
  number	= 10 <0,1e9>	: number of spikes
  start		= 50 (ms)	: start of first spike
  noise		= 0 <0,1>	: amount of randomeaness (0.0 - 1.0)
  end		= 1e9 (ms)	: time to terminate train
}

ASSIGNED {
  event (ms)
  on
  endt (ms)
  type
  id
}

CONSTRUCTOR {
  VERBATIM 
  { if (ifarg(1)) { id= *getarg(1); } else { id= -1; }
    if (ifarg(2)) { type= *getarg(2); } else { type= 1; }
  }
  ENDVERBATIM
}

PROCEDURE seed (x) {
  set_seed(x)
}

INITIAL {
  on = 0
  if (noise < 0) { noise = 0 }
  if (noise > 1) { noise = 1 }
  if (interval <= 0.) { interval = .01 (ms) }
  if (start>=0 && number>0 && end>0) {
    event = start + invl(interval) - interval*(1. - noise)
    if (event < 0) { event = 0 }
    net_send(event, 3)
  }
}	

PROCEDURE init_sequence (t(ms)) {
  if (number > 0) {
    on = 1
    event = t
    endt = t + 1e-6 + interval*(number-1)
  }
}

FUNCTION invl (mean (ms)) (ms) {
  if (noise == 0) {
    invl = mean
  } else {
    invl = (1. - noise)*mean + noise*mean*exprand(1)
  }
}

NET_RECEIVE (w) {
  if (flag == 0) { : external event
    if (w > 0 && on == 0) { : turn on spike sequence
      init_sequence(t)
      net_send(0, 1)
    } else if (w < 0 && on == 1) { : turn off spiking
      on = 0
    }
  }
  if (flag == 3) { : from INITIAL
    if (on == 0) {
      init_sequence(t)
      net_send(0, 1)
    }
  }
  if (flag == 1 && on == 1) {
    net_event(t)
    event = event + invl(interval)
    if (event > endt || event > end) {
      on = 0
    } else {
      net_send(event - t, 1)
    }
  }
}

FUNCTION fflag () { fflag=1 }

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