Gamma and theta rythms in biophysical models of hippocampus circuits (Kopell et al. 2011)


Help downloading and running models
Accession:138421
" ... the main rhythms displayed by the hippocampus, the gamma (30–90 Hz) and theta (4–12 Hz) rhythms. We concentrate on modeling in vitro experiments, but with an eye toward possible in vivo implications. ... We use simpler biophysical models; all cells have a single compartment only, and the interneurons are restricted to two types: fast-spiking (FS) basket cells and oriens lacunosum-moleculare (O-LM) cells. ... , we aim not so much at reproducing dynamics in great detail, but at clarifying the essential mechanisms underlying the production of the rhythms and their interactions (Kopell, 2005). ..."
References:
1 . Tort AB, Rotstein HG, Dugladze T, Gloveli T, Kopell NJ (2007) On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampus. Proc Natl Acad Sci U S A 104:13490-5 [PubMed]
2 . Gloveli T, Dugladze T, Rotstein HG, Traub RD, Monyer H, Heinemann U, Whittington MA, Kopell N (2005) Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus. Proc Natl Acad Sci U S A 102:13295-300 [PubMed]
3 . Kopell N, Borgers C, Pervouchine D, Malerba P, Tort ABL (2010) Gamma and theta rhythms in biophysical models of hippocampal circuits Hippocampal Microcircuits: A Computational Modeller`s Resource Book. Ch. 15., Cutsuridis V, Graham BF, Cobb S, Vida I, ed.
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell; Hippocampus CA3 pyramidal cell; Hippocampus CA1 interneuron oriens alveus; Neocortex fast spiking (FS) interneuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB (web link to model);
Model Concept(s): Oscillations;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; Hippocampus CA3 pyramidal cell; Hippocampus CA1 interneuron oriens alveus; GabaA; AMPA; I Na,t; I K;
(located via links below)
Loading data, please wait...