Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)

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Accession:139421
"Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare, OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta. ..."
Reference:
1 . Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Ketamine disrupts theta modulation of gamma in a computer model of hippocampus Journal of Neuroscience 31(32):11733-11743 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s): I L high threshold; I A; I K; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; NMDA; Glutamate;
Gene(s): HCN1; HCN2;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Oscillations; Synchronization; Therapeutics; Pathophysiology; Schizophrenia; Information transfer; Brain Rhythms;
Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Neymotin, Sam [samn at neurosim.downstate.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; GabaA; NMDA; Glutamate; I L high threshold; I A; I K; I K,Ca; Gaba; Glutamate;
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hpcdemo
readme.html
CA1ih.mod *
CA1ika.mod *
CA1ikdr.mod *
CA1ina.mod *
caolmw.mod *
capr.mod *
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: $Id: ihpyrkop.mod,v 1.1 2009/11/05 15:11:39 samn Exp $ 
COMMENT

//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
//
// NOTICE OF COPYRIGHT AND OWNERSHIP OF SOFTWARE
//
// Copyright 2007, The University Of Pennsylvania
// 	School of Engineering & Applied Science.
//   All rights reserved.
//   For research use only; commercial use prohibited.
//   Distribution without permission of Maciej T. Lazarewicz not permitted.
//   mlazarew@seas.upenn.edu
//
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

This mode file is based on the paper:

Tort, A. B., Rotstein, H. G., Dugladze, T., et al. (2007). On the formation of gamma-coherent cell
assemblies by oriens lacunosum-moleculare interneurons in the hippocampus. Proc Natl Acad Sci U S A.

ENDCOMMENT

NEURON {
	SUFFIX IhPyrKop
    NONSPECIFIC_CURRENT i
	RANGE v50, gmax
}
	
UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(mS) = (millisiemens)
}

PARAMETER {
    gmax =   0.0  (mS/cm2)
    eh   = -30.0  (mV)
    v50  =   0.0 (mV)
}
    
ASSIGNED { 

    v (mV)
    i (mA/cm2)
}

STATE { q }

INITIAL { q  = qinf(v) }

BREAKPOINT {

	SOLVE states METHOD cnexp
	
    i = (1e-3) * gmax * q * (v-eh)
}

DERIVATIVE states { q' = (qinf(v)-q)/qtau(v) }

FUNCTION qinf(v(mV))     { qinf = fun2(v, v50, 1.0, 10.5)*1.0(ms) }
FUNCTION qtau(v(mV))(ms) { qtau = 1.0(ms)/(exp((-14.59(mV)-0.086*v)/1.0(mV)) + exp((-1.87(mV)+0.0701*v)/1.0(mV))) }

:HCN1
:FUNCTION qinf(v(mV))     { qinf = fun2(v, v50, 1, 1.0/0.151)*1(ms) }
:FUNCTION qtau(v(mV))(ms) { qtau = exp(0.033(/mV)*(v+75))/(0.011*(1+exp(0.083(/mV)*(v+75))))*1(ms)}

INCLUDE "aux_fun.inc"

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