Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)

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Accession:139421
"Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare, OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta. ..."
Reference:
1 . Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Ketamine disrupts theta modulation of gamma in a computer model of hippocampus Journal of Neuroscience 31(32):11733-11743 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal cell; Hippocampus CA3 interneuron basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s): I L high threshold; I A; I K; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; NMDA; Glutamate;
Gene(s): HCN1; HCN2;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Oscillations; Synchronization; Therapeutics; Pathophysiology; Schizophrenia; Information transfer; Brain Rhythms;
Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Neymotin, Sam [samn at neurosim.downstate.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; Hippocampus CA3 interneuron basket cell; GabaA; NMDA; Glutamate; I L high threshold; I A; I K; I K,Ca; Gaba; Glutamate;
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hpcdemo
readme.html
CA1ih.mod *
CA1ika.mod *
CA1ikdr.mod *
CA1ina.mod *
caolmw.mod *
capr.mod *
icaolmw.mod *
icapr.mod *
iholmkop.mod *
iholmw.mod *
ihpyrkop.mod *
kahppr.mod *
kaolmkop.mod *
kapyrkop.mod *
kcaolmw.mod *
kcpr.mod *
kdrbwb.mod *
kdrolmkop.mod *
kdrpr.mod *
kdrpyrkop.mod *
misc.mod *
MyExp2Syn.mod *
MyExp2SynAlpha.mod *
MyExp2SynBB.mod *
MyExp2SynNMDA.mod *
MyExp2SynNMDABB.mod *
nafbwb.mod *
nafolmkop.mod *
nafpr.mod *
nafpyrkop.mod *
stats.mod
vecst.mod *
wrap.mod *
aux_fun.inc *
declist.hoc *
decmat.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
drline.hoc *
geom.hoc *
geom.py *
grvec.hoc *
init.hoc *
labels.hoc *
local.hoc *
misc.h *
mosinit.py
network.py *
nqs.hoc *
nqs_utils.hoc *
nrnoc.hoc *
params.py
pyinit.py *
run.py
screenshot.png
simctrl.hoc *
stats.hoc *
syncode.hoc *
xgetargs.hoc *
                            
: $Id: wrap.mod,v 1.1 2010/12/21 19:56:41 samn Exp $ 

NEURON {
THREADSAFE
 SUFFIX wrap
 GLOBAL INSTALLED
 GLOBAL verbose
}

PARAMETER {
  INSTALLED=0
  verbose=0
}

VERBATIM

#include <math.h>
#include <stdlib.h>

double* wrap(double* x,int n,int flen){
  double* y = (double*) calloc(n,sizeof(double));
  int i,j=0;
  for(i=flen/2+1;i<flen;i++)    y[j++]=x[i];
  j=n-flen/2-1;
  for(i=0;i<=flen/2;i++)   y[j++]=x[i];
  return y;
}

void wraparound(void* vv) {
  double* x,*y;
  int vsz,fsz,i;
  vsz = vector_instance_px(vv,&x);
  fsz = (int) *getarg(1);
  if(fsz > vsz) {
    printf("wraparound ERRA: invalid filter len %d > vector len %d!\n",fsz,vsz);
    return;
  }
  y = wrap(x,vsz,fsz);
  for(i=0;i<vsz;i++) x[i]=y[i];
  free(y);
}

ENDVERBATIM

PROCEDURE install () {
  if (INSTALLED==1) {
    printf("already installed wrap.mod")
  } else {
    INSTALLED=1
    VERBATIM
    install_vector_method("wraparound",wraparound);
    ENDVERBATIM
  }
}

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