Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)

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Accession:139421
"Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare, OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta. ..."
Reference:
1 . Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Ketamine disrupts ? modulation of ? in a computer model of hippocampus. J Neurosci 31:11733-43 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal cell; Hippocampus CA3 interneuron basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s): I L high threshold; I A; I K; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; NMDA; Glutamate;
Gene(s): HCN1; HCN2;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Oscillations; Synchronization; Therapeutics; Pathophysiology; Schizophrenia; Information transfer; Brain Rhythms;
Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Neymotin, Sam [samn at neurosim.downstate.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; Hippocampus CA3 interneuron basket cell; GabaA; NMDA; Glutamate; I L high threshold; I A; I K; I K,Ca; Gaba; Glutamate;
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hpcdemo
readme.html
CA1ih.mod *
CA1ika.mod *
CA1ikdr.mod *
CA1ina.mod *
caolmw.mod *
capr.mod *
icaolmw.mod *
icapr.mod *
iholmkop.mod *
iholmw.mod *
ihpyrkop.mod *
kahppr.mod *
kaolmkop.mod *
kapyrkop.mod *
kcaolmw.mod *
kcpr.mod *
kdrbwb.mod *
kdrolmkop.mod *
kdrpr.mod *
kdrpyrkop.mod *
misc.mod *
MyExp2Syn.mod *
MyExp2SynAlpha.mod *
MyExp2SynBB.mod *
MyExp2SynNMDA.mod *
MyExp2SynNMDABB.mod *
nafbwb.mod *
nafolmkop.mod *
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nafpyrkop.mod *
stats.mod
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mosinit.py
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params.py
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simctrl.hoc *
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xgetargs.hoc *
                            
: $Id: CA1ina.mod,v 1.4 2010/11/30 19:50:00 samn Exp $ 
TITLE INa CA1

UNITS {
  (mA) = (milliamp)
  (mV) = (millivolt)
}

NEURON {
  SUFFIX nacurrent
  NONSPECIFIC_CURRENT ina
  RANGE g, e, vi, ki
  RANGE minf,hinf,iinf,mtau,htau,itau : testing
}
  
PARAMETER {
  : v	    (mV)
  celsius	    (degC)
  g = 0.032   (mho/cm2)
  e = 55	    (mV)
  vi = -60    (mV)
  ki = 0.8
}
 
STATE {
  m
  h
  I : i 
}
 
ASSIGNED {
  i (mA/cm2)
  ina	(mA/cm2) 
  minf
  mtau    (ms)
  hinf
  htau	(ms)
  iinf
  itau	(ms)
  v	(mV) : testing
}

: PROCEDURE iassign () { ina=g*m*m*m*h*i*(v-e) }
PROCEDURE iassign () { i=g*m*m*m*h*I*(v-e) ina=i}
 
BREAKPOINT {
  SOLVE states METHOD cnexp
  iassign()
}
 
DERIVATIVE states { 
  rates(v)
  m' = (minf - m) / mtau
  h' = (hinf - h) / htau
  : i' = (iinf - i) / itau	    
  I' = (iinf - I) / itau	    
}

INITIAL { 
  rates(v)
  h = hinf
  m = minf
  : i = iinf
  I = iinf
  iassign() : testing
}


PROCEDURE rates(v (mV)) {
  LOCAL  a, b
  UNITSOFF
  a = 0.4*(v+30)/(1-exp(-(v+30)/7.2))
  b = 0.124*(v+30)/(exp((v+30)/7.2)-1) 	
  mtau=0.5/(a+b)
  if (mtau<0.02) {mtau=0.02}
  minf=a/(a+b)
  a = 0.03*(v+45)/(1-exp(-(v+45)/1.5))
  b = 0.01*(v+45)/(exp((v+45)/1.5)-1)
  htau=0.5/(a+b)
  if (htau<0.5) {htau=0.5}
  hinf=1/(1+exp((v+50)/4))
  a =	exp(0.45*(v+66))
  b = exp(0.09*(v+66))
  itau=3000*b/(1+a)
  if (itau<10) {itau=10}
  iinf=(1+ki*exp((v-vi)/2))/(1+exp((v-vi)/2))
  UNITSON
}


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