Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)

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Accession:139421
"Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multi-compartment neurons (pyramidal, basket and oriens-lacunosum moleculare, OLM, cells) generated theta and gamma oscillations from intrinsic network dynamics: basket cells primarily generated gamma and amplified theta, while OLM cells strongly contributed to theta. ..."
Reference:
1 . Neymotin SA, Lazarewicz MT, Sherif M, Contreras D, Finkel LH, Lytton WW (2011) Ketamine disrupts theta modulation of gamma in a computer model of hippocampus Journal of Neuroscience 31(32):11733-11743 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s): I L high threshold; I A; I K; I K,Ca;
Gap Junctions:
Receptor(s): GabaA; NMDA; Glutamate;
Gene(s): HCN1; HCN2;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python;
Model Concept(s): Oscillations; Synchronization; Therapeutics; Pathophysiology; Schizophrenia; Information transfer; Brain Rhythms;
Implementer(s): Lazarewicz, Maciej [mlazarew at gmu.edu]; Neymotin, Sam [samn at neurosim.downstate.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; GabaA; NMDA; Glutamate; I L high threshold; I A; I K; I K,Ca; Gaba; Glutamate;
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hpcdemo
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CA1ih.mod *
CA1ika.mod *
CA1ikdr.mod *
CA1ina.mod *
caolmw.mod *
capr.mod *
icaolmw.mod *
icapr.mod *
iholmkop.mod *
iholmw.mod *
ihpyrkop.mod *
kahppr.mod *
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kcpr.mod *
kdrbwb.mod *
kdrolmkop.mod *
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kdrpyrkop.mod *
misc.mod *
MyExp2Syn.mod *
MyExp2SynAlpha.mod *
MyExp2SynBB.mod *
MyExp2SynNMDA.mod *
MyExp2SynNMDABB.mod *
nafbwb.mod *
nafolmkop.mod *
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nafpyrkop.mod *
stats.mod
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: $Id: nafbwb.mod,v 1.4 2010/12/13 21:35:08 samn Exp $ 
COMMENT

//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
//
// NOTICE OF COPYRIGHT AND OWNERSHIP OF SOFTWARE
//
// Copyright 2007, The University Of Pennsylvania
// 	School of Engineering & Applied Science.
//   All rights reserved.
//   For research use only; commercial use prohibited.
//   Distribution without permission of Maciej T. Lazarewicz not permitted.
//   mlazarew@seas.upenn.edu
//
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

ENDCOMMENT

UNITS {
  (mA) = (milliamp)
  (mV) = (millivolt)
  (mS) = (millisiemens)
}

NEURON {
  SUFFIX Nafbwb
  USEION na WRITE ina
  RANGE phih
  RANGE gna, ena, taoh : testing
}
	
PARAMETER {
  gna  = 35 (mS/cm2)
  ena  = 55 (mV)
  phih = 5
}
    
ASSIGNED {
  v       (mV)
  ina     (mA/cm2)
  minf    (1)
  hinf    (1)
  taoh    (ms)
  celsius (degC)
}

STATE { h }

PROCEDURE iassign () { ina = (1e-3) * gna * minf^3 * h * (v-ena) }

INITIAL {
  rates(v)
  h = hinf
  iassign()
}

BREAKPOINT {
  SOLVE states METHOD cnexp	
  iassign()
}

DERIVATIVE states { 
  rates(v)
  h' = (hinf-h)/taoh
}

PROCEDURE rates(v(mV)) { LOCAL am, bm, ah, bh, q10
    
  q10  = phih:^((celsius-27.0(degC))/10.0(degC))	
    
  am   = fun3(v,  -35, -0.1,    -10)
  bm   = fun1(v,  -60,  4,      -18) 
  minf = am/(am+bm)
 
  ah   = fun1(v,  -58,    0.07,  -20)
  bh   = fun2(v,  -28,    1,     -10)
  hinf = ah/(ah+bh)
  taoh = 1./((ah+bh)*q10)
}

INCLUDE "aux_fun.inc"

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