Frog second-order vestibular neuron models (Rossert et al. 2011)

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Accession:139654
This implements spiking Hodgkin-Huxley type models of tonic and phasic second-order vestibular neurons. Models fitted to intracellular spike and membrane potential recordings from frog (Rana temporaria). The models can be stimulated by intracellular step current, frequency current (ZAP) or synaptic stimulation.
Reference:
1 . Rossert C, Straka H, Moore LE, Glasauer S (2011) Cellular and network contributions to vestibular signal processing: impact of ion conductances, synaptic inhibition and noise. J Neurosci 31:8359-8372
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Vestibular neuron; Abstract Morris-Lecar neuron;
Channel(s): I T low threshold; I K,Ca; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Glycine; Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Simplified Models; Action Potentials; Sensory processing; Vestibular;
Implementer(s): Roessert, Christian [christian.a at roessert.de];
Search NeuronDB for information about:  I T low threshold; I K,Ca; I Sodium; I Potassium; Glycine; Gaba; Glutamate;
begintemplate cell
public soma, dend

create soma, dend[1]

objref skca // ONLY IN SOMA POSSIBLE, CHANGE SOMETHING TO ALSO ADD IT TO DEND

proc init() {

    N = $1
    rho = $2
    Le = $3
    CS = $4     // pF
    GS = $5     // nS
    GSh = $6    // nS        
    GNa = $7    // S/cm2
    GK = $8     // S/cm2
    GKd = $9    // S/cm2
    tfac = $10
    GKCa = $11  // mS/cm2
    El = $13    // mV $12
    Els = $13   // mV
    bn = $14 
    gn = $15
    tn = $16
    tca = $17

    create soma, dend[N]

    Gcore = (rho*N*GS*1e-9)/(Le*Le)                     // S
    Rcore = 1/Gcore                                     // Ohm

    soma {

        nseg = 1
        cm = 1                                      // uF/cm2
        CM = CS * 1e-6                              // uF
        Area = CM / cm                              // (uF/(uF/cm2)) = cm2     
        l = sqrt(Area/PI)                           // cm
        diam = l * 1e4                              // um
        L = l * 1e4                                 // um
    
        insert fh 
        gnabar_fh = GNa                             // S/cm2
        gkbar_fh = 0
        gl_fh = (GS+GSh) * 1e-9 / Area              // nS
        el_fh = Els                                  // mV
        vsh_fh = -70

        Rm = 1/gl_fh                                // Ohm cm2

        Ra = (Rcore/L)*PI*(diam/2)*(diam/2)*1e-4    // Ohm cm

        insert kml 
        gbar_kml =  GK     // S/cm2
        bn_kml = bn 
        gn_kml = gn
        tn_kml = tn

        if(GKd!=0) {
            insert klt
            gbar_klt = GKd    // S/cm2
            tfac_klt = tfac
        }

        ek = -90
        ena = 55

        if(GKCa!=0) {
            skca = new KCa(0.5)
            skca.dgkbar = GKCa // mS/cm2
            skca.egk   = -90
            skca.ctau =  tca
            skca.thresh = -10
        }

    }

    for i=0, N-1 dend[i] {

        nseg = 1
        cm = 1                                      // uF/cm2
        CM = (rho/N) * CS * 1e-6                    // uF
        Area = CM / cm                              // (uF/(uF/cm2)) = cm2     
        l = sqrt(Area/PI)                           // cm
        diam = l * 1e4                              // um
        L = l * 1e4                                 // um

        insert leak
        g_leak = (rho/N) * GS * 1e-9 / Area         // nS
        Er_leak = El                               // (mV)
        Rm = 1/g_leak                               // Ohm cm2

        Ra = (Rcore/L)*PI*(diam/2)*(diam/2)*1e-4    // Ohm cm
        
    }

    connect dend[0](0), soma(1)
    if(N>1) {
        for k=0, N-2 {
            connect dend[k+1](0), dend[k](1)
        }
    }
}

endtemplate cell

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