Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)

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Accession:139656
" ... Previous one-dimensional network modeling of the cerebellar granular layer has been successfully linked with a range of cerebellar cortex oscillations observed in vivo. However, the recent discovery of gap junctions between Golgi cells (GoCs), which may cause oscillations by themselves, has raised the question of how gap-junction coupling affects GoC and granular-layer oscillations. To investigate this question, we developed a novel two-dimensional computational model of the GoC-granule cell (GC) circuit with and without gap junctions between GoCs. ..."
Reference:
1 . Simões de Souza F, De Schutter E (2011) Robustness effect of gap junctions between Golgi cells on cerebellar cortex oscillations Neural Systems & Circuits 1:7:1-19
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum interneuron granule cell; Cerebellum golgi cell;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA; NMDA;
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Synchronization; Action Potentials;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  Cerebellum interneuron granule cell; GabaA; AMPA; NMDA;
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network
data
README.txt
gap.mod
Golgi_BK.mod *
Golgi_Ca_HVA.mod *
Golgi_Ca_LVA.mod *
Golgi_CALC.mod *
Golgi_CALC_ca2.mod *
Golgi_hcn1.mod *
Golgi_hcn2.mod *
Golgi_KA.mod *
Golgi_KM.mod *
Golgi_KV.mod *
Golgi_lkg.mod *
Golgi_Na.mod *
Golgi_NaP.mod *
Golgi_NaR.mod *
Golgi_SK2.mod *
GRC_CA.mod *
GRC_CALC.mod *
GRC_KA.mod *
GRC_KCA.mod *
GRC_KIR.mod *
GRC_KM.mod *
GRC_KV.mod *
GRC_LKG1.mod *
GRC_LKG2.mod *
GRC_NA.mod *
K_conc.mod *
Na_conc.mod *
Golgi_ComPanel.hoc *
Golgi_template.hoc
granule_template.hoc
MF_template.hoc
mosinit.hoc
network.hoc
utils.hoc *
                            
//DEFINITION OF CELL TEMPLATE

begintemplate fibre

public Presynapse
public x,y,z
public StimTrigger

objref StimTrigger

public nclist
objectvar nclist  

//counting spikes
public spiketimes,spikecount
objref spiketimes,spikecount

public syn 
objectvar syn 

public voltagem
objref voltagem

create Presynapse	//create compartment

proc init() {

x=$1
y=$2
z=$3

spiketimes=new Vector()
lastspikecount=0

voltagem=new Vector()


Presynapse {

 //initialise and clear the 3D information
 pt3dclear()
 pt3dadd(x,y,z,10)	//set position of cell
 pt3dadd(x,y,z+10,10)
 diam=1.0
 L=1
 nclist=new List()
 StimTrigger=new NetStim(0.5) //Adding spike generator

nseg=1
diam=10.0
L=5
Ra=123
insert hh	//Hodgkin-Huxley channels
gnabar=0.25
gl_hh=.0001666
el_hh=-60 
syn=new ExpSyn(0) //Adding synapse


//counting spikes
spikecount=new APCount(0.5)
spikecount.thresh=-20
spikecount.record(spiketimes)

//Saving Vm
voltagem.record(&v(0.5))
}
}

endtemplate fibre

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