Cerebellar cortex oscil. robustness from Golgi cell gap jncs (Simoes de Souza and De Schutter 2011)

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Accession:139656
" ... Previous one-dimensional network modeling of the cerebellar granular layer has been successfully linked with a range of cerebellar cortex oscillations observed in vivo. However, the recent discovery of gap junctions between Golgi cells (GoCs), which may cause oscillations by themselves, has raised the question of how gap-junction coupling affects GoC and granular-layer oscillations. To investigate this question, we developed a novel two-dimensional computational model of the GoC-granule cell (GC) circuit with and without gap junctions between GoCs. ..."
Reference:
1 . Simões de Souza F, De Schutter E (2011) Robustness effect of gap junctions between Golgi cells on cerebellar cortex oscillations Neural Systems & Circuits 1:7:1-19
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum interneuron granule cell; Cerebellum golgi cell;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s): GabaA; AMPA; NMDA;
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Oscillations; Synchronization; Action Potentials;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at ufabc.edu.br];
Search NeuronDB for information about:  Cerebellum interneuron granule cell; GabaA; AMPA; NMDA;
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network
data
README.txt
gap.mod
Golgi_BK.mod *
Golgi_Ca_HVA.mod *
Golgi_Ca_LVA.mod *
Golgi_CALC.mod *
Golgi_CALC_ca2.mod *
Golgi_hcn1.mod *
Golgi_hcn2.mod *
Golgi_KA.mod *
Golgi_KM.mod *
Golgi_KV.mod *
Golgi_lkg.mod *
Golgi_Na.mod *
Golgi_NaP.mod *
Golgi_NaR.mod *
Golgi_SK2.mod *
GRC_CA.mod *
GRC_CALC.mod *
GRC_KA.mod *
GRC_KCA.mod *
GRC_KIR.mod *
GRC_KM.mod *
GRC_KV.mod *
GRC_LKG1.mod *
GRC_LKG2.mod *
GRC_NA.mod *
K_conc.mod *
Na_conc.mod *
Golgi_ComPanel.hoc *
Golgi_template.hoc
granule_template.hoc
MF_template.hoc
mosinit.hoc
network.hoc
utils.hoc *
                            
TITLE Cerebellum Golgi Cell Model

COMMENT
        Calcium first order kinetics
   
	Author: A. Fontana
	Revised: 12.12.98
ENDCOMMENT

NEURON {
        SUFFIX Golgi_CALC_ca2
        USEION ca2 READ ica2, ca2o WRITE ca2i VALENCE 2
        RANGE d, beta, ca2i0, ca2_pump_i
}

UNITS {
        (mV)    = (millivolt)
        (mA)    = (milliamp)
	(um)    = (micron)
	(molar) = (1/liter)
        (mM)    = (millimolar)
   	F      = (faraday) (coulomb)
}

PARAMETER {
        ica2             (mA/cm2)
        celsius    (degC)
        d = .2          (um)
        ca2o        (mM)         
        ca2i0     (mM)         
        beta = 1.3        (/ms)
}
ASSIGNED {
	ca2_pump_i	(mA)
}

STATE {
	ca2i (mM)
}

INITIAL {
        ca2i = ca2i0 
}

BREAKPOINT {
       SOLVE conc METHOD derivimplicit
}

DERIVATIVE conc {    
	:  outward ionic current with valence 2+
	ca2_pump_i = 2*beta*(ca2i-ca2i0)
	:  total outward Ca2 current
	ca2i' = -ica2/(2*F*d)*(1e4) - beta*(ca2i-ca2i0)
}



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