A multi-compartment model for interneurons in the dLGN (Halnes et al. 2011)

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Accession:140249
This model for dLGN interneurons is presented in two parameterizations (P1 & P2), which were fitted to current-clamp data from two different interneurons (IN1 & IN2). The model qualitatively reproduces the responses in IN1 & IN2 under 8 different experimental condition, and quantitatively reproduces the I/O-relations (#spikes elicited as a function of injected current).
Reference:
1 . Halnes G, Augustinaite S, Heggelund P, Einevoll GT, Migliore M (2011) A multi-compartment model for interneurons in the dorsal lateral geniculate nucleus. PLoS Comput Biol 7:e1002160 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus lateral geniculate nucleus interneuron;
Channel(s): I L high threshold; I T low threshold; I CAN; I Sodium; I Mixed; I Potassium; I_AHP;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Active Dendrites; Detailed Neuronal Models; Rebound firing;
Implementer(s): Halnes, Geir [geir.halnes at nmbu.no];
Search NeuronDB for information about:  I L high threshold; I T low threshold; I CAN; I Sodium; I Mixed; I Potassium; I_AHP;
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dLGN_modelDB
readme.html
Cad.mod *
HH_traub.mod *
iahp.mod *
iar.mod *
ical.mod *
Ican.mod *
it2.mod *
091008A2.hoc *
fixnseg.hoc *
INmodel.hoc
INmodel.ses
mosinit.hoc
Parameters1.hoc
Parameters2.hoc
screenshot1.jpg
screenshot2.jpg
screenshot3.jpg
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TITLE decay of internal calcium concentration
:
: Simple extrusion mechanism for internal calium dynamics
:
: Written by Alain Destexhe, Salk Institute, Nov 12, 1992
: Modified by Geir Halnes, Norwegian Life Science University of Life Sciences, June 2011


INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	SUFFIX Cad
	USEION Ca READ iCa, Cai WRITE Cai VALENCE 2
	RANGE Cainf,taur,k
}

UNITS {
	(molar) = (1/liter)			: moles do not appear in units
	(mM)	= (millimolar)
	(um)	= (micron)
	(mA)	= (milliamp)
	(msM)	= (ms mM)
}


PARAMETER {
	depth	= .1(um)		: depth of shell
	taur	= 50	(ms)		: Zhu et al. used 2 decay terms w/ taus 80ms and 150ms. 1 term 50 ms gives similar decay. 
	Cainf	= 5e-5	(mM)  : Basal Ca-level
	Cainit  = 5e-5 (mM)	: Initial Ca-level
      k       = 0.0155458135   (mmol/C cm)  : Phenomenological constant, estimated to give reasonable intracellular calcium concentration
}


STATE {
	Cai		(mM) <1e-8> : to have tolerance of .01nM
}


INITIAL {
	Cai = Cainit
}


ASSIGNED {
	iCa		(mA/cm2)
	drive_channel	(mM/ms)
	drive_pump	(mM/ms)
}

	
BREAKPOINT {
	SOLVE state METHOD cnexp
}

DERIVATIVE state { 
	drive_channel =  - k * iCa
	if (drive_channel<=0.) { drive_channel = 0. }: cannot pump inward
	Cai' = drive_channel +(Cainf-Cai)/taur
}

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