Firing patterns in stuttering fast-spiking interneurons (Klaus et al. 2011)

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Accession:140254
This is a morphologically extended version of the fast-spiking interneuron by Golomb et al. (2007). The model captures the stuttering firing pattern and subthreshold oscillations in response to step current input as observed in many cortical and striatal fast-spiking cells.
Reference:
1 . Klaus A, Planert H, Hjorth J, Berke JD, Silberberg G, Kotaleski JH (2011) Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact Front. Syst. Neurosci.
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum fast spiking interneuron;
Channel(s): I Na,t; I K; I A, slow;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS; PGENESIS;
Model Concept(s): Activity Patterns; Stuttering;
Implementer(s): Klaus, Andreas ;
Search NeuronDB for information about:  I Na,t; I K; I A, slow;
/
fsn-stutt
channels
ampa_channel.g
gaba_channel.g
Kd_chan.g
Kdr_chan.g
NaT_chan.g
                            
/**
 * Activation
 */
function Kd_ainf(Vm)
    float Vm
    float v = 1.0e3 * {Vm} /* Volt to Millivolt. */
    return {1.0 / {1.0 + {exp {{{-50.0} - {v}} / {20.0}}}}}
end

/**
 * Inactivation.
 */
function Kd_binf(Vm)
    float Vm
    float v = 1.0e3 * {Vm} /* Volt to Millivolt. */
    return {1.0 / {1.0 + {exp {{{-70.0} - {v}} / {-6.0}}}}}
end

function make_Kd_chan

    str path = "Kd_chan"
    float Erev = -0.090  /* reversal potential of sodium */

    float xmin = -0.100   /* minimum voltage we will see in the simulation */
    float xmax =  0.050   /* maximum voltage we will see in the simulation */
    float step =  0.005   /* use a 5mV step size */
    int xdivs  =  30      /* the number of divisions between -0.1 and 0.05 */
    int i

    create tabchannel {path}

    /* make the table for the activation with a range of -100mV - +50mV
     * with an entry for ever 5mV
     */
    call {path} TABCREATE X {xdivs} {xmin} {xmax}
    call {path} TABCREATE Y {xdivs} {xmin} {xmax}

    /* set the tau and m_inf for the activation and inactivation */
    for(i = 0; i < {xdivs} + 1; i = i + 1)
        setfield {path} X_A->table[{i}] {0.002}
        setfield {path} X_B->table[{i}] {Kd_ainf   {{xmin} + {i * {step}}}}
        setfield {path} Y_A->table[{i}] {0.150}
        setfield {path} Y_B->table[{i}] {Kd_binf   {{xmin} + {i * {step}}}}
    end

    setfield {path} Ek {Erev} Xpower 3 Ypower 1

    tweaktau {path} X
    tweaktau {path} Y

    call {path} TABFILL X 3000 0
    call {path} TABFILL Y 3000 0

    setfield {path} X_A->calc_mode 0 X_B->calc_mode 0
    setfield {path} Y_A->calc_mode 0 Y_B->calc_mode 0
end


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