Firing patterns in stuttering fast-spiking interneurons (Klaus et al. 2011)

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Accession:140254
This is a morphologically extended version of the fast-spiking interneuron by Golomb et al. (2007). The model captures the stuttering firing pattern and subthreshold oscillations in response to step current input as observed in many cortical and striatal fast-spiking cells.
Reference:
1 . Klaus A, Planert H, Hjorth J, Berke JD, Silberberg G, Kotaleski JH (2011) Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact Front. Syst. Neurosci.
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum fast spiking interneuron;
Channel(s): I Na,t; I K; I A, slow;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS; PGENESIS;
Model Concept(s): Activity Patterns; Stuttering;
Implementer(s): Klaus, Andreas ;
Search NeuronDB for information about:  I Na,t; I K; I A, slow;
/
fsn-stutt
channels
ampa_channel.g
gaba_channel.g
Kd_chan.g
Kdr_chan.g
NaT_chan.g
                            
/* 
 * interneuron simulation
 * Copyright (C) 2000 Rory Kirchner (rory@mail.csh.rit.edu)
 *
 * This program is free software; you can redistribute it and/or
 * modify it under the terms of the GNU General Public License
 * as published by the Free Software Foundation; either version 2
 * of the License, or (at your option) any later version.
 *
 * This program is distributed in the hope that it will be useful,
 * but WITHOUT ANY WARRANTY; without even the implied warranty of
 * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
 * GNU General Public License for more details.
 * 
 * You should have received a copy of the GNU General Public License
 * along with this program; if not, write to the Free Software
 * Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA  02111-1307, USA
 *
 */

function make_GABA_channel

   str chanpath = "GABA_channel"
// cf Bartos et al 2001, Dunning et al 1999, Ling et al 1998
//adjust to Avramas data instead
//   float tau1 = 2e-3
//   float tau2 = 6e-3
   float tau1 = 1.33e-3
   float tau2 = 4e-3
//was 2 and 6e-3 before

   float gmax = 0.0
   float Ek = -0.060

   create synchan {chanpath}

   setfield {chanpath} tau1 {tau1} tau2 {tau2} gmax {gmax} Ek {Ek}

end



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