Firing patterns in stuttering fast-spiking interneurons (Klaus et al. 2011)

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Accession:140254
This is a morphologically extended version of the fast-spiking interneuron by Golomb et al. (2007). The model captures the stuttering firing pattern and subthreshold oscillations in response to step current input as observed in many cortical and striatal fast-spiking cells.
Reference:
1 . Klaus A, Planert H, Hjorth J, Berke JD, Silberberg G, Kotaleski JH (2011) Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact Front. Syst. Neurosci.
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum fast spiking interneuron;
Channel(s): I Na,t; I K; I A, slow;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS; PGENESIS;
Model Concept(s): Activity Patterns; Stuttering;
Implementer(s): Klaus, Andreas ;
Search NeuronDB for information about:  I Na,t; I K; I A, slow;
/*
 * This model includes a transient (fast) sodium channel, and two potassium
 * channels: a delayed rectifier (Kv3.1-3.2) and the d-type potassium current
 * with fast activation and slow inactivation.
 * The conductances were taken from:
 *      Golomb, Donner, Shacham, Shlosberg, Amitai Y, et al. (2007)
 *      Mechanisms of Firing Patterns in Fast-Spiking Cortical Interneurons.
 *      PLoS Comput Biol 3(8): e156. doi:10.1371/journal.pcbi.0030156.
 */

include ./channels/NaT_chan
include ./channels/Kdr_chan
include ./channels/Kd_chan

include ./channels/ampa_channel
include ./channels/gaba_channel


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