Firing patterns in stuttering fast-spiking interneurons (Klaus et al. 2011)

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Accession:140254
This is a morphologically extended version of the fast-spiking interneuron by Golomb et al. (2007). The model captures the stuttering firing pattern and subthreshold oscillations in response to step current input as observed in many cortical and striatal fast-spiking cells.
Reference:
1 . Klaus A, Planert H, Hjorth J, Berke JD, Silberberg G, Kotaleski JH (2011) Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact Front. Syst. Neurosci.
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum fast spiking interneuron;
Channel(s): I Na,t; I K; I A, slow;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS; PGENESIS;
Model Concept(s): Activity Patterns; Stuttering;
Implementer(s): Klaus, Andreas ;
Search NeuronDB for information about:  I Na,t; I K; I A, slow;
*relative
*cartesian
*asymmetric
*lambda_warn

*set_compt_param RM 1.2    // Ohm*m^2
*set_compt_param CM 0.007  // F/m^2
*set_compt_param RA 2.0    // Ohm*m
*set_compt_param EREST_ACT -0.065
*set_compt_param ELEAK     -0.065

*start_cell /library/tert_dend
   tert_dend   none  30    0    0    0.50  AMPA_channel  -1.0e-12
   tert_dend2  .     30    0    0    0.50  AMPA_channel  -1.0e-12
   tert_dend3  .     30    0    0    0.50  AMPA_channel  -1.0e-12
   tert_dend4  .     30    0    0    0.50  AMPA_channel  -1.0e-12
   tert_dend5  .     30    0    0    0.50  AMPA_channel  -1.0e-12
   tert_dend6  .     30    0    0    0.50  AMPA_channel  -1.0e-12
   tert_dend7  .     30    0    0    0.50  AMPA_channel  -1.0e-12
   tert_dend8  .     30    0    0    0.50  AMPA_channel  -1.0e-12
*makeproto /library/tert_dend

*start_cell /library/sec_dend
   sec_dend    none  37    0    0    0.75  AMPA_channel  -1.0e-12  GABA_channel -1.0e-12
   sec_dend2   .     37    0    0    0.75  AMPA_channel  -1.0e-12  GABA_channel -1.0e-12
   sec_dend3   .     37    0    0    0.75  AMPA_channel  -1.0e-12  GABA_channel -1.0e-12
   sec_dend4   .     37    0    0    0.75  AMPA_channel  -1.0e-12  GABA_channel -1.0e-12
*makeproto /library/sec_dend

*start_cell /library/prim_dend
   prim_dend   none  45    0    0    1.00  NaT_chan        225.0   Kdr_chan 450.0  Kd_chan 1.6  \
                                           AMPA_channel -1.0e-12   GABA_channel -1.0e-12
   prim_dend2  .     45    0    0    1.00  NaT_chan        225.0   Kdr_chan 450.0  Kd_chan 1.6  \
                                           AMPA_channel -1.0e-12   GABA_channel -1.0e-12
*makeproto /library/prim_dend

*start_cell 
  soma   none  15  0  0 15  NaT_chan         2250.0  Kdr_chan 4500.0  Kd_chan 16.0  \
                            AMPA_channel   -1.0e-12  GABA_channel   -1.0e-12

*compt /library/prim_dend
primdend1   soma                  45    0    0    1.0
primdend2   soma                  45    0    0    1.0
primdend3   soma                  45    0    0    1.0
 
*compt /library/sec_dend
secdend1    primdend1/prim_dend2  37    0    0    0.75
secdend2    primdend1/prim_dend2  37    0    0    0.75
secdend3    primdend2/prim_dend2  37    0    0    0.75 
secdend4    primdend2/prim_dend2  37    0    0    0.75
secdend5    primdend3/prim_dend2  37    0    0    0.75
secdend6    primdend3/prim_dend2  37    0    0    0.75

*compt /library/tert_dend
tertdend1   secdend1/sec_dend4    30    0    0    0.5 
tertdend2   secdend1/sec_dend4    30    0    0    0.5 
tertdend3   secdend2/sec_dend4    30    0    0    0.5 
tertdend4   secdend2/sec_dend4    30    0    0    0.5 
tertdend5   secdend3/sec_dend4    30    0    0    0.5 
tertdend6   secdend3/sec_dend4    30    0    0    0.5 
tertdend7   secdend4/sec_dend4    30    0    0    0.5
tertdend8   secdend4/sec_dend4    30    0    0    0.5
tertdend9   secdend5/sec_dend4    30    0    0    0.5 
tertdend10  secdend5/sec_dend4    30    0    0    0.5 
tertdend11  secdend6/sec_dend4    30    0    0    0.5
tertdend12  secdend6/sec_dend4    30    0    0    0.5

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