Firing patterns in stuttering fast-spiking interneurons (Klaus et al. 2011)

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Accession:140254
This is a morphologically extended version of the fast-spiking interneuron by Golomb et al. (2007). The model captures the stuttering firing pattern and subthreshold oscillations in response to step current input as observed in many cortical and striatal fast-spiking cells.
Reference:
1 . Klaus A, Planert H, Hjorth J, Berke JD, Silberberg G, Kotaleski JH (2011) Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact Front. Syst. Neurosci.
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum fast spiking interneuron;
Channel(s): I Na,t; I K; I A, slow;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: GENESIS; PGENESIS;
Model Concept(s): Activity Patterns; Stuttering;
Implementer(s): Klaus, Andreas ;
Search NeuronDB for information about:  I Na,t; I K; I A, slow;
/**
 * This method calculates the somatic, dendritic, and total area of the
 * membrane surface.
 * 
 * path - The path to the cell.
 */
function printStatsArea(path)
	str path
	str comp
	
	float pi   = 3.14159
	float dia, len, area_soma = 0.0, area_total = 0.0
	
	/* Get the total membrane area. */
	area_total = 0.0
	foreach comp ({el {path}/##[TYPE=compartment]})
		dia = {getfield {comp} dia}
		len = {getfield {comp} len}
		area_total = {{area_total} + {{pi} * {dia} * {len}}}
		//echo {comp}" "{{pi} * {dia} * {len}}
	end

	dia = {getfield {path}/soma dia}
	len = {getfield {path}/soma len}
	area_soma = {{pi} * {dia} * {len}}

	echo "Membrane surface: "{area_total}" m^2"
	echo "A_s       = "{area_soma}
	echo "A_d       = "{ {area_total} - {area_soma}}
	echo "A_d / A_s = "{{{area_total} - {area_soma}} / {area_soma}}
end

/**
 * This function adjusts the resting potential so that the leak current is in a steady state.
 */
function setVrest(path)
	str   path
	str   comppath, chanpath
	float Em, Isum
	
	foreach comppath ({el {path}/##[TYPE=compartment]})
		
		Isum = 0.0
		foreach chanpath ({el {comppath}/##[TYPE=tabchannel]})
			Isum = {Isum} + {getfield {chanpath} Ik}
		end
    	Em = {{getfield {comppath} Vm} - {Isum} * {getfield {comppath} Rm}}
    	setfield {comppath} Em {Em}
	end
end

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