Dendritic Discrimination of Temporal Input Sequences (Branco et al. 2010)

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Accession:140828
Compartmental model of a layer 2/3 pyramidal cell in the rat somatosensory cortex, exploring NMDA-dependent sensitivity to the temporal sequence of synaptic activation.
References:
1 . Branco T, Clark BA, Häusser M (2010) Dendritic discrimination of temporal input sequences in cortical neurons. Science 329:1671-5 [PubMed]
2 . Branco T, Häusser M (2011) Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron 69:885-92 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Dendrite;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Spatio-temporal Activity Patterns; Synaptic Integration; Direction Selectivity;
Implementer(s):
Search NeuronDB for information about:  Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell; NMDA; Glutamate;
/*--------------------------------------------------------
Insert passive and active properties in rc19 cell. 

Option to have non-uniform resting Vm in basal dendrites

Tiago Branco (2010)
--------------------------------------------------------*/

proc init_params() {
    celsius = 37
    Cm = 1
    Rm = 10000  
    Ri = 150
    v_init = -75  
}


//-------------------------------------------------------
//add passive properties
//-------------------------------------------------------   

proc init_passive(){
    forall {insert pas g_pas = 1/Rm e_pas=v_init cm=Cm Ra=Ri}
    axon {g_pas = 0.02}
}

proc nonunif_rm(){
    a = $1
    dendid = $2
    x=1
    access dend[dendid]
    for(x,0) {
	gm = 1/Rm*(1+2*a*(x-1/2))
	g_pas(1-x) = gm
    }
}



//-------------------------------------------------------
//add active properties
//-------------------------------------------------------   
proc init_active_params(){
    Ek = -90
    Ena = 60
    Eca = 140
    vshift_na = -5
    vshift_ca = 0
    
    gna_axon = 30000
    gkv_axon = 400
    
    gna_soma = 1500
    gkv_soma = 200
    gkm_soma = 2.2
    gkca_soma = 2.5
    gca_soma = 0.5
    git_soma = 0.0003
    
    gna_dend = 40      
    gkv_dend = 30      
    gkm_dend = 0.05    
    gkca_dend = 2.5   
    gca_dend = 0.5  
    git_dend = 0.0006
    gh_dend = 0
}

proc init_active(){
    
    forsec axonal {
	insert na          gbar_na = gna_axon
        insert kv          gbar_kv = gkv_axon
    }
    
    forsec somatic {
	insert na          gbar_na = gna_soma
	insert kv          gbar_kv = gkv_soma
	insert km          gbar_km = gkm_soma
	insert kca         gbar_kca = gkca_soma
	insert ca          gbar_ca = gca_soma
	insert it          gbar_it = git_soma
    }

    forsec basal {
	insert na          gbar_na = gna_dend
	insert kv          gbar_kv = gkv_dend
	insert km          gbar_km = gkm_dend
	insert kca         gbar_kca = gkca_dend
	insert ca          gbar_ca = gca_dend
	insert it          gbar_it = git_dend
	insert hd          ghdbar_hd = gh_dend
}
   
   forall if(ismembrane("k_ion"))  ek = Ek
   forall if(ismembrane("na_ion")) ena = Ena
   forall if(ismembrane("ca_ion")) {
       ion_style("ca_ion",0,1,0,0,0)
       vshift_ca = 0
  }
}

    
    

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