Dendritic Discrimination of Temporal Input Sequences (Branco et al. 2010)

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Accession:140828
Compartmental model of a layer 2/3 pyramidal cell in the rat somatosensory cortex, exploring NMDA-dependent sensitivity to the temporal sequence of synaptic activation.
References:
1 . Branco T, Clark BA, Häusser M (2010) Dendritic discrimination of temporal input sequences in cortical neurons. Science 329:1671-5 [PubMed]
2 . Branco T, Häusser M (2011) Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron 69:885-92 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Dendrite;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s):
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Spatio-temporal Activity Patterns; Synaptic Integration; Direction Selectivity;
Implementer(s):
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; NMDA; Glutamate;
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Branco_2010
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ar.mod
ca.mod *
cad.mod *
caL3d.mod *
CaT.mod *
h.mod *
HH2.mod *
inwardrect.mod
kca.mod *
kir.mod *
km.mod *
kv.mod *
na.mod *
NMDA_Mg_T.mod *
release_BMK.mod *
                            
TITLE transmitter release

COMMENT
-----------------------------------------------------------------------------

 
   References:

   Destexhe, A., Mainen, Z.F. and Sejnowski, T.J. Synthesis of models for
   excitable membranes, synaptic transmission and neuromodulation using a 
   common kinetic formalism, Journal of Computational Neuroscience 1: 
   195-230, 1994.

   Destexhe, A., Mainen, Z.F. and Sejnowski, T.J.  Kinetic models of 
   synaptic transmission.  In: Methods in Neuronal Modeling (2nd edition; 
   edited by Koch, C. and Segev, I.), MIT press, Cambridge, 1996.

  Written by Bjoern Kampa, 2004

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ENDCOMMENT


INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	SUFFIX rel
	RANGE T, del, dur, amp
}

UNITS {
	(mM) = (milli/liter)
}

PARAMETER {
	del (ms)
	dur (ms)	<0,1e9>
	amp (mM)
}

ASSIGNED { T (mM)
}


INITIAL {
	T = 0
}

BREAKPOINT {
	at_time(del)
	at_time(del+dur)

	if (t < del + dur && t > del) {
		T = amp
	}else{
		T = 0
	}
}



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