Network model with neocortical architecture (Anderson et al 2007,2012; Azhar et al 2012)

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Accession:141507
Architecturally realistic neocortical model using seven classes of excitatory and inhibitory single compartment Hodgkin-Huxley cells. This is an addendum to ModelDB Accession # 98902, Studies of stimulus parameters for seizure disruption (Anderson et al. 2007). Wiring is adapted from the minicolumn hypothesis and incorporates visual and neocortical wiring data. Simulation demonstrates spontaneous bursting onset and cessation. This activity can be induced by random fluctuations in the surrounding background input.
References:
1 . Anderson WS, Kudela P, Cho J, Bergey GK, Franaszczuk PJ (2007) Studies of stimulus parameters for seizure disruption using neural network simulations. Biol Cybern 97:173-94 [PubMed]
2 . Anderson WS, Kudela P, Weinberg S, Bergey GK, Franaszczuk PJ (2009) Phase-dependent stimulation effects on bursting activity in a neural network cortical simulation. Epilepsy Res 84:42-55 [PubMed]
3 . Anderson WS, Azhar F, Kudela P, Bergey GK, Franaszczuk PJ (2012) Epileptic seizures from abnormal networks: why some seizures defy predictability. Epilepsy Res 99:202-13 [PubMed]
4 . Azhar F, Anderson WS (2012) Predicting single-neuron activity in locally connected networks. Neural Comput 24:2655-77 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell; Neocortex V1 interneuron basket PV cell; Neocortex fast spiking (FS) interneuron;
Channel(s): I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium;
Gap Junctions:
Receptor(s): AMPA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program;
Model Concept(s): Bursting; Epilepsy;
Implementer(s):
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-5 cell; Neocortex V1 interneuron basket PV cell; AMPA; Gaba; I A; I K; I K,leak; I K,Ca; I Sodium; I Calcium;
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AndersonEtAl2011
readme.txt
0.net
0.par *
0.stim
0.sub
Ca_sum.c
clust_cn.c
clust_cn.h *
crl.c *
jhist.c *
link_sort.c *
lnet.h
mkhist.c *
mklink.c
mknode.c
mkpar.c *
Movie1.mpg
netclustwacnmdadiff.c
nodes.16
rnetcolumn *
rnetcolumn.txt *
sublink.c *
                            
These are the files for a paper under review: and a fresh paper:

Anderson WS, Azhar F, Kudela P, Bergey GK, Franaszczuk PJ. Epileptic
seizures from abnormal networks: Why some seizures defy
predictability. Epi Res doi: 10.1016/j.eplepsyres.2011.11.006.

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