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Compartmentalization of GABAergic inhibition by dendritic spines (Chiu et al. 2013)
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A spiny dendrite model supports the hypothesis that only inhibitory inputs on spine heads, not shafts, compartmentalizes inhibition of calcium signals to spine heads as seen in paired inhibition with back-propagating action potential experiments on prefrontal cortex layer 2/3 pyramidal neurons in mouse (Chiu et al. 2013).
Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ (2013) Compartmentalization of GABAergic inhibition by dendritic spines.
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Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell;
I L high threshold;
Dendritic Action Potentials;
Influence of Dendritic Geometry;
Carnevale, Ted [Ted.Carnevale at Yale.edu];
Morse, Tom [Tom.Morse at Yale.edu];
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Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell
I L high threshold
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10x dend inhib with bAP (widespread inhib with smaller change in amplitude)
spine inhibiton with bAP (compartmentalized inhibition)
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