Compartmentalization of GABAergic inhibition by dendritic spines (Chiu et al. 2013)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:143604
A spiny dendrite model supports the hypothesis that only inhibitory inputs on spine heads, not shafts, compartmentalizes inhibition of calcium signals to spine heads as seen in paired inhibition with back-propagating action potential experiments on prefrontal cortex layer 2/3 pyramidal neurons in mouse (Chiu et al. 2013).
Reference:
1 . Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ (2013) Compartmentalization of GABAergic inhibition by dendritic spines. Science 340:759-62 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I K;
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Influence of Dendritic Geometry;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; GabaA; I Na,t; I L high threshold; I K;
 
/
singleDendrite
hoc
optimization
sealed_end
add_soma.hoc
annotate_bAP_envelope_graph.ses
ca_current._graphses *
ca_current_graph.ses *
ca_graph.ses
convenient_tasks.hoc
demo_choice.hoc
den_v_170_180_190.ses
dend_shaft_bAP_functions.hoc
dend_shaft_bAP_inhib.hoc
dend_spine_cai.ses
dendrite_morphology.hoc
electrotonic_length.hoc
GABA_A_ReceptorDistribution.hoc
hyperpol.hoc
impedance_conditions.hoc
impedance_frequencies.hoc
init_figs.hoc
insert_synapses.hoc
int2mstr.hoc
MainenCurrentDistribution.hoc
mulRunFit_s1_inhib_s0_not.ses
mulRunFit_s1_inhib_s0_not.ses.fd1 *
mulRunFit_s1_inhib_s0_not.ses.ft1
mulRunFitDendInhib.ses
mulRunFitDendInhib.ses.fd1 *
mulRunFitDendInhib.ses.ft1
mulRunFitRatio.ses
mulRunFitRatio.ses.fd1 *
mulRunFitRatio.ses.ft1
mulRunFitRatio_cm.ses
mulRunFitRatio_cm.ses.fd1 *
mulRunFitRatio_cm.ses.ft1
multi_cond_declare_vecs.hoc
multi_cond_setup_vecs.hoc
MultIClamp.ses
multiplerunfit.txt
run_impedance_study.hoc
run_over_Rm.hoc
runcntrl_graphs_iclamp.ses
setup_write_vecs_standard.hoc
specific_cases.hoc
spine_placement.hoc
spine_template.hoc
systematic_exploration.hoc
v_dend_spine.ses
v_soma_spine_dend.ses
variable_dt_off.ses
variable_time_step.ses
zrun.hoc
                            
File not selected

<- Select file from this column.
Loading data, please wait...