Compartmentalization of GABAergic inhibition by dendritic spines (Chiu et al. 2013)

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Accession:143604
A spiny dendrite model supports the hypothesis that only inhibitory inputs on spine heads, not shafts, compartmentalizes inhibition of calcium signals to spine heads as seen in paired inhibition with back-propagating action potential experiments on prefrontal cortex layer 2/3 pyramidal neurons in mouse (Chiu et al. 2013).
Reference:
1 . Chiu CQ, Lur G, Morse TM, Carnevale NT, Ellis-Davies GC, Higley MJ (2013) Compartmentalization of GABAergic inhibition by dendritic spines. Science 340:759-62 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell;
Channel(s): I Na,t; I L high threshold; I K;
Gap Junctions:
Receptor(s): GabaA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Influence of Dendritic Geometry;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu];
Search NeuronDB for information about:  Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; I Na,t; I L high threshold; I K;
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singleDendrite
mod
ca.mod
ca_a1g.mod
ca_a1h.mod *
cad.mod
constant.mod
distr.mod *
exp2syncur.mod
exp2synsat.mod
im.mod *
kca.mod *
km.mod *
kv.mod
multiclamp.mod
na.mod
zoidsyn.mod *
                            
TITLE CaT channel alpha-1G from McRory et al, 2001
: Reversal potential described by Nernst equation
: M.Migliore Jan 2003

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(molar) = (1/liter)
	(mM) = (millimolar)
	FARADAY = (faraday) (coulomb)
	R = (k-mole) (joule/degC)
}

PARAMETER {
	v (mV)
	celsius		(degC)
	gbar=.008 (mho/cm2)
        vhalfn=-51.73   (mV)
        vhalfl=-85.4   (mV)
        kn=6.53   (1)
        kl=-5.4   (1)
	q10=2.3
	cai 	= 0.00665315 (mM): .00005 (mM)	: initial [Ca]i = 50 nM
	cao 	= 2	(mM)	: [Ca]o = 2 mM
	eca
}


NEURON {
	SUFFIX cat1g
	USEION ca READ eca WRITE ica
        RANGE gbar, carev, ica
        GLOBAL ninf,linf,taul,taun, q10
}

STATE {
	n
        l
}

ASSIGNED {
	ica	(mA/cm2)		: current
	carev	(mV)			: rev potential
        ninf
        linf      
        taul
        taun
}

INITIAL {
	rates(v)
	n=ninf
	l=linf
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	carev = (1e3) * (R*(celsius+273.15))/(2*FARADAY) * log (cao/cai)
	ica = gbar*n*l*(v-carev)
}


DERIVATIVE states {     : exact when v held constant; integrates over dt step
        rates(v)
        n' = (ninf - n)/taun
        l' =  (linf - l)/taul
}

PROCEDURE rates(v (mV)) { :callable from hoc
        LOCAL a,qt
        qt=q10^((celsius-22)/10)
        ninf = 1/(1 + exp(-(v-vhalfn)/kn))
        linf = 1/(1 + exp(-(v-vhalfl)/kl))
        taun = (0.5+0.124*exp(-v/15.8))/qt
        taul = (10.4+0.0118*exp(-v/7.85))/qt
}















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