CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)

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Accession:143719
NEURON files from the paper: On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons by D.Bianchi, A. Marasco, A.Limongiello, C.Marchetti, H.Marie,B.Tirozzi, M.Migliore (2012). J Comput. Neurosci. In press. DOI: 10.1007/s10827-012-0383-y. Experimental findings shown that under sustained input current of increasing strength neurons eventually stop firing, entering a depolarization block. We analyze the spiking dynamics of CA1 pyramidal neuron models using the same set of ionic currents on both an accurate morphological reconstruction and on its reduction to a single-compartment. The results show the specic ion channel properties and kinetics that are needed to reproduce the experimental findings, and how their interplay can drastically modulate the neuronal dynamics and the input current range leading to depolarization block.
Reference:
1 . Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012) On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons J Comput. Neurosci. 33:207-25 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K; I M; I h; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Mathematica;
Model Concept(s): Simplified Models; Depolarization block; Bifurcation;
Implementer(s): Bianchi, Daniela [danielabianchi12 -at- gmail.com]; Limongiello, Alessandro [alessandro.limongiello at unina.it];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; GabaA; AMPA; NMDA; I Na,t; I A; I K; I M; I h; I K,Ca; I_AHP; Gaba; Glutamate;
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Ca1_Bianchi
experiment
lib
morphology
template
readme.txt
Biforcation0.nb
                            
NEURON and Mathematica files from the paper:

On the mechanisms underlying the depolarization block in the spiking
dynamics of CA1 pyramidal neurons by D.Bianchi, A. Marasco,
A.Limongiello, C.Marchetti, H.Marie,B.Tirozzi, M.Migliore (2012).
J Comput Neurosci.

The CA1 morphological neuron model has been implemented starting by
merging model files from Poirazi et al. (ModelDB accession number
20212), and from Shah et al. (ModelDB accession number 112546),
adapting a few parameters from their original values to take into
account the specific set of experimental traces used in this work, as
discussed in the Appendix of the paper.

The Simulation.hoc file in the "experiment" directory will reproduce
the results in Fig. 5 of the paper.

The Mathematica file refers to the bifurcation analysis of the
specific somatic model used in the paper.
The file will be visualized correctly with Mathematica, so save it on
your pc and then open with the software.

To run the simulation which will reproduce the results in Fig. 9, type
SHIFT + ENTER in the current Mathematica session.

Questions on the NEURON simulation should be addressed to
(replace -at- with the usual @ symbol):
danielabianchi12-at-gmail.com
daniela.bianchi-at-roma1.infn.it

Questions on the Mathematica file should be addressed to
(replace -at- with the usual @ symbol):
alessandro.limongiello-at-unina.it

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