Advanced search
SenseLab
SimToolDB
ModelDB Help
User account
Login
Register
Find models by
Model name
First author
Each author
Region(circuits)
Find models for
Cell type
Current
Receptor
Gene
Transmitters
Concept
Simulators
Methods
Find models of
Realistic Networks
Neurons
Electrical synapses (gap junctions)
Chemical synapses
Ion channels
Neuromuscular junctions
Axons
Pathophysiology
Other resources
SenseLab mailing list
ModelDB related resources
Computational neuroscience ecosystem
Models in a git repository
CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)
Download zip file
Auto-launch
Help downloading and running models
Model Information
Model File
Citations
Model Views
Accession:
143719
NEURON files from the paper: On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons by D.Bianchi, A. Marasco, A.Limongiello, C.Marchetti, H.Marie,B.Tirozzi, M.Migliore (2012). J Comput. Neurosci. In press. DOI: 10.1007/s10827-012-0383-y. Experimental findings shown that under sustained input current of increasing strength neurons eventually stop firing, entering a depolarization block. We analyze the spiking dynamics of CA1 pyramidal neuron models using the same set of ionic currents on both an accurate morphological reconstruction and on its reduction to a single-compartment. The results show the specic ion channel properties and kinetics that are needed to reproduce the experimental findings, and how their interplay can drastically modulate the neuronal dynamics and the input current range leading to depolarization block.
Reference:
1 .
Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012) On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons.
J Comput Neurosci
33
:207-25
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Hippocampus;
Cell Type(s):
Hippocampus CA1 pyramidal cell;
Channel(s):
I Na,t;
I A;
I K;
I M;
I h;
I K,Ca;
I_AHP;
Gap Junctions:
Receptor(s):
GabaA;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Mathematica;
Model Concept(s):
Simplified Models;
Depolarization block;
Bifurcation;
Implementer(s):
Bianchi, Daniela [danielabianchi12 -at- gmail.com];
Limongiello, Alessandro [alessandro.limongiello at unina.it];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal cell
;
GabaA
;
AMPA
;
NMDA
;
I Na,t
;
I A
;
I K
;
I M
;
I h
;
I K,Ca
;
I_AHP
;
Gaba
;
Glutamate
;
Download the displayed file
/
Ca1_Bianchi
experiment
cad.mod
*
Other models using cad.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
cagk.mod
*
Other models using cagk.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
cal.mod
*
Other models using cal.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron (Combe et al 2018)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
calH.mod
*
Other models using calH.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
car.mod
*
Other models using car.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
cat.mod
*
Other models using cat.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
d3.mod
*
Other models using d3.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
CA1 pyramidal neuron (Combe et al 2018)
CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
CA1 pyramidal neuron: dendritic Ca2+ inhibition (Muellner et al. 2015)
CA1 pyramidal neuron: synaptic plasticity during theta cycles (Saudargiene et al. 2015)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
h.mod
*
Other models using h.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
kadist.mod
*
Other models using kadist.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
kaprox.mod
*
Other models using kaprox.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
kca.mod
*
Other models using kca.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
kdr.mod
*
Other models using kdr.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
km.mod
*
Other models using km.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
na3.mod
*
Other models using na3.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
na3dend.mod
*
Other models using na3dend.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
na3notrunk.mod
*
Other models using na3notrunk.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
nap.mod
*
Other models using nap.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
nax.mod
*
Other models using nax.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
somacar.mod
*
Other models using somacar.mod:
Amyloid-beta effects on release probability and integration at CA3-CA1 synapses (Romani et al. 2013)
Effects of increasing CREB on storage and recall processes in a CA1 network (Bianchi et al. 2014)
cell-setup.hoc
mosinit.hoc
sessio.ses
Simulation.hoc
load_file("Simulation.hoc")
Load Model View
Loading data, please wait...