CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)

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Accession:143719
NEURON files from the paper: On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons by D.Bianchi, A. Marasco, A.Limongiello, C.Marchetti, H.Marie,B.Tirozzi, M.Migliore (2012). J Comput. Neurosci. In press. DOI: 10.1007/s10827-012-0383-y. Experimental findings shown that under sustained input current of increasing strength neurons eventually stop firing, entering a depolarization block. We analyze the spiking dynamics of CA1 pyramidal neuron models using the same set of ionic currents on both an accurate morphological reconstruction and on its reduction to a single-compartment. The results show the specic ion channel properties and kinetics that are needed to reproduce the experimental findings, and how their interplay can drastically modulate the neuronal dynamics and the input current range leading to depolarization block.
Reference:
1 . Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012) On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons J Comput. Neurosci. 33:207-25 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K; I M; I h; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Mathematica;
Model Concept(s): Simplified Models; Depolarization block; Bifurcation;
Implementer(s): Bianchi, Daniela [danielabianchi12 -at- gmail.com]; Limongiello, Alessandro [alessandro.limongiello at unina.it];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; GabaA; AMPA; NMDA; I Na,t; I A; I K; I M; I h; I K,Ca; I_AHP; Gaba; Glutamate;
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Ca1_Bianchi
experiment
cad.mod *
cagk.mod *
cal.mod *
calH.mod *
car.mod *
cat.mod *
d3.mod *
h.mod *
kadist.mod *
kaprox.mod *
kca.mod *
kdr.mod *
km.mod *
na3.mod *
na3dend.mod *
na3notrunk.mod *
nap.mod *
nax.mod *
somacar.mod *
cell-setup.hoc
mosinit.hoc
sessio.ses
Simulation.hoc
                            
TITLE  Na persistent channel
: used in distal oblique dendrites to assist Ca spike initiation  
: 
: modified to use CVode --Carl Gold 08/12/03
:  Updated by YiotaPoirazi   26/1/05

NEURON {
	SUFFIX nap
	USEION na READ ena WRITE ina
        RANGE  gnabar,vhalf, K, ina

}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {            
	K = 4.5            (1)      : slope of steady state variable
:	gnabar = 0.001e-2 (mho/cm2) : suggested conductance, 1 percent of the transient Na current
	gnabar = 0        (mho/cm2)
	vhalf  = -50.4    (mV)      : half potential
      
}	

ASSIGNED {
	v             (mV)
        ena           (mV)    
	ina           (mA/cm2)
        n_inf
        tau            (ms)
}

STATE { n }

BREAKPOINT {
	SOLVE states METHOD cnexp
	ina = gnabar*n*n*n*(v-ena)
}

INITIAL {
	rates(v)
	n = n_inf
}


DERIVATIVE states {
        rates(v)
        n' = (n_inf-n)/tau
}

PROCEDURE rates(v(mV)) {
	n_inf = 1 / (1 + (exp(vhalf - v)/K))
	tau =1
}




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