CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)

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Accession:143719
NEURON files from the paper: On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons by D.Bianchi, A. Marasco, A.Limongiello, C.Marchetti, H.Marie,B.Tirozzi, M.Migliore (2012). J Comput. Neurosci. In press. DOI: 10.1007/s10827-012-0383-y. Experimental findings shown that under sustained input current of increasing strength neurons eventually stop firing, entering a depolarization block. We analyze the spiking dynamics of CA1 pyramidal neuron models using the same set of ionic currents on both an accurate morphological reconstruction and on its reduction to a single-compartment. The results show the specic ion channel properties and kinetics that are needed to reproduce the experimental findings, and how their interplay can drastically modulate the neuronal dynamics and the input current range leading to depolarization block.
Reference:
1 . Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012) On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons. J Comput Neurosci 33:207-25 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I M; I h; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Mathematica;
Model Concept(s): Simplified Models; Depolarization block; Bifurcation;
Implementer(s): Bianchi, Daniela [danielabianchi12 -at- gmail.com]; Limongiello, Alessandro [alessandro.limongiello at unina.it];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; AMPA; NMDA; I Na,t; I A; I K; I M; I h; I K,Ca; I_AHP; Gaba; Glutamate;
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Ca1_Bianchi
lib
basic-graphics.hoc *
current-balance.hoc *
cut-sections.hoc *
map-segments-to-3d.hoc *
vector-distance.hoc *
                            
// This function creates a new graphical display and allows printing
// of graphs to eps files.
// edited by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

objref win[200]
ngraph = 0

proc addgraph() {       // define subroutine to add a new graph
                        // addgraph("variable", minvalue, maxvalue)
        ngraph = ngraph+1
        windex = ngraph-1
        win[windex] = new Graph()
        win[windex].size(0,tstop,$2,$3)
//      win[windex].view(0,$2,tstop,$3-$2,0,0,600,100)  // only for printing
        win[windex].xaxis()
        win[windex].yaxis()
        win[windex].label(0.1,1.0)
        win[windex].addvar($s1,1,0)
        win[windex].save_name("graphList[0].")
        graphList[0].append(win[windex])
}

proc addgraph_and_soma() {      // define subroutine to add a new graph
                                // addgraph("variable", minvalue, maxvalue)
        ngraph = ngraph+1
        windex = ngraph-1
        win[windex] = new Graph()
        win[windex].size(0,tstop,$2,$3)
//      win[windex].view(0,$2,tstop,$3-$2,0,0,600,100)  // only for printing
        win[windex].xaxis()
        win[windex].yaxis()
        win[windex].label(0.1,1.0)
        win[windex].addvar($s1,5,0)
        win[windex].addvar("soma.v(0.5)",1,0)
        win[windex].save_name("graphList[0].")
        graphList[0].append(win[windex])
}


if(ismenu==0) {
  nrnmainmenu()                 // create main menu
  nrncontrolmenu()              // crate control menu
  ismenu=1
}
proc addgraph_2() {             // define subroutine to add a new graph
                                // addgraph("variable", minvalue, maxvalue)
        ngraph = ngraph+1
        windex = ngraph-1
        win[windex] = new Graph()
        win[windex].size($2,$3,$4,$5)
//      win[windex].view(0,$2,tstop,$3-$2,0,0,600,100)  // only for printing
        win[windex].xaxis()
        win[windex].yaxis()
        win[windex].label(0.1,1.0)
        win[windex].addvar($s1,1,0)
        win[windex].save_name("graphList[0].")
        graphList[0].append(win[windex])
}


proc graph_label() {             // define subroutine to re-label a graph
                                 // graph_label("variable", minvalue, maxvalue)
        win[windex].erase_all()                        
        win[windex].size($2,$3,$4,$5)
        win[windex].xaxis()
        win[windex].yaxis()
        win[windex].label(0.1,1)
        win[windex].addvar($s1,1,0)

}

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