CA1 pyramidal neuron: depolarization block (Bianchi et al. 2012)

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Accession:143719
NEURON files from the paper: On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons by D.Bianchi, A. Marasco, A.Limongiello, C.Marchetti, H.Marie,B.Tirozzi, M.Migliore (2012). J Comput. Neurosci. In press. DOI: 10.1007/s10827-012-0383-y. Experimental findings shown that under sustained input current of increasing strength neurons eventually stop firing, entering a depolarization block. We analyze the spiking dynamics of CA1 pyramidal neuron models using the same set of ionic currents on both an accurate morphological reconstruction and on its reduction to a single-compartment. The results show the specic ion channel properties and kinetics that are needed to reproduce the experimental findings, and how their interplay can drastically modulate the neuronal dynamics and the input current range leading to depolarization block.
Reference:
1 . Bianchi D, Marasco A, Limongiello A, Marchetti C, Marie H, Tirozzi B, Migliore M (2012) On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons. J Comput Neurosci 33:207-25 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I M; I h; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Mathematica;
Model Concept(s): Simplified Models; Depolarization block; Bifurcation;
Implementer(s): Bianchi, Daniela [danielabianchi12 -at- gmail.com]; Limongiello, Alessandro [alessandro.limongiello at unina.it];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; AMPA; NMDA; I Na,t; I A; I K; I M; I h; I K,Ca; I_AHP; Gaba; Glutamate;
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Ca1_Bianchi
template
BasalPath.hoc *
ExperimentControl.hoc *
load_templates.hoc
ObliquePath.hoc *
RangeRef.hoc *
                            
// This template creates the Basal Path lists, starting from the
// section attached to the trunk and ending with the basal tip section 
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

begintemplate BasalPath

public basal_dtrunk_to_tip, basal_trunk_section, root_basal

strdef sexec

objref basal_trunk_section
strdef basal_trunk_section_name

objref root_basal
strdef root_basal_name

objref basal_tip_section
strdef basal_tip_section_name

objref basal_path

proc init () {
  sec_count=0

  forsec $o1 {

    if (sec_count==1) {
       root_basal    = new SectionRef()
       root_basal_name=secname()
    }
      
    if (!sec_count) {
       distance(0,1)
       basal_trunk_section  = new SectionRef()
       basal_trunk_section_name=secname()
      }
    sec_count=sec_count+1

    basal_tip_section    = new SectionRef()
    basal_tip_section_name=secname()
  }

  access root_basal.sec
  distance(0,0)
  access basal_tip_section.sec
  basal_dtrunk_to_tip=distance(1,1)

//printf("BasalPath basal_trunk_section: %s root_basal: %s basal_tip_section: %s distance between root_basal and basal_tip_section: %g\n", basal_trunk_section_name, root_basal_name, basal_tip_section_name, basal_dtrunk_to_tip)
}

endtemplate BasalPath

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