Synchrony by synapse location (McTavish et al. 2012)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:144054
This model considers synchrony between mitral cells induced via shared granule cell interneurons while taking into account the spatial constraints of the system. In particular, since inhibitory inputs decay passively along the lateral dendrites, this model demonstrates that an optimal arrangement of the inhibitory synapses will be near the cell bodies of the relevant mitral cells.
Reference:
1 . McTavish TS, Migliore M, Shepherd GM, Hines ML (2012) Mitral cell spike synchrony modulated by dendrodendritic synapse location. Front Comput Neurosci 6:3 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Synchronization; Olfaction;
Implementer(s): McTavish, Thomas S [thomas.mctavish at yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; GabaB; AMPA; NMDA; I Na,t; I A; I K;
/
mctavish_syncbylocation
src
ampanmda.mod
fi.mod
kamt.mod
kdrmt.mod
naxn.mod
ThreshDetect.mod *
allsynhinton.hoc *
analysis.py
animtest.py
antest.ses *
bulbspikes.py
clear.hoc
connect.hoc
control.ses
default.hoc
granule.hoc *
hinton.hoc
init.hoc *
iterator.hoc *
lptiter.hoc
mgrs.hoc
michele_movie.hoc
mitral.hoc
mosinit.hoc
net.hoc
param.hoc
params.py
parinit.hoc
pattern.hoc
perfrun.hoc
show.hoc
showw.hoc
somesyn.hoc *
sortspike *
split.hoc
start.hoc
start.ses
stimodors.hoc
subset.hoc
subset_control.ses *
synweightsnapshot.py
viewspikes.hoc
viewspikes1.hoc
weight_movie.hoc
weightsave.hoc
                            
begintemplate ScreenUpdateHandler
public begin, flush, view_count, add, remove
external flush_list
objref this
strdef stmt
proc init() {
	stmt = $s1
}
proc add() {
	if (flush_list.index(this) == -1) {
		flush_list.append(this) }
	}
proc remove() { local i
	i = flush_list.index(this)
	if (i > -1) {
		flush_list.remove(i)
	}
}
proc begin() {
	//printf("%s.begin %g\n", this, t)
}
proc flush() {
	//printf("%s.flush %g\n", this, t)
	execute(stmt)
}
func view_count() {
	//printf("%s.view_count %g\n", this, t)
	return 1
}
endtemplate ScreenUpdateHandler

objref gl, gls[num_mitral+num_granule], tvt, rt, tvi, tvs
tvt= new Vector(0)
tvi= new Vector(0)
tvs= new Vector(0)

proc gly() {
gl.erase()
gl.path()
gl.m(t,0)
gl.l(t,num_mitral)
gl.s(8,3)
}

proc glys() {local s, x
    s=$1
    if (s<num_mitral){
	gls[s].path()
	x=8
	gls[s].m(0,x*1.1547)
	gls[s].l(-x,-x)
	gls[s].l(x,-x)
	gls[s].close()
	gls[s].fill(s+1)
    } else {
	x = 4
	gls[s].path()
	gls[s].m(-x, -x)
	gls[s].l(-x, x)
	gls[s].l(x, x)
	gls[s].l(x, -x)
	gls[s].close()
	gls[s].fill(8)
    }
}


objref bh

proc barinit() {
	if (object_id(bh) == 0) {
		bh = new ScreenUpdateHandler("bar()")
		bh.add()
	}
	gl = new Glyph()
	gly()
	sc_.grasterm_.glyph(gl, 0, 0)
	sc_.grasterm_.flush()
}

proc bar() {
	gly()
	sc_.grasterm_.flush()
	//cvode.event(t + 20, "bar()")
}

objref spikes_hnd
proc spikesinit() { local m, next   localobj tv, s
	if (object_id(spikes_hnd) == 0) {
		spikes_hnd = new ScreenUpdateHandler("spikeson()")
		spikes_hnd.add()
	}
	idx = 0
	sc_.draw()
	s = new String()
	for m=0, num_mitral+num_granule-1 {
		gls[m] = new Glyph()
		if (m<num_mitral) {
//			sc_.g.glyph(gls[m],m+896,(m-4)/12)
			sc_.g.glyph(gls[m],mitral_x.x[m], m, 1,1,0,1)
		}else{
//			sc_.g.glyph(gls[m],(m-5)*10,-1)
			sc_.g.glyph(gls[m],granule_x.x[m-num_mitral],-1, 1,1,0,1)
		}
	}
}


proc spikeson() {local m, i, tt
        //printf("spikeson %d %g\n", idx, t)
	if (idx >= pattern_idvec_.size) { return }
	tt = pattern_tvec_.x[idx]
	for m=0, num_mitral + num_granule -1 {
		gls[m].erase()
	}
	// light up if a spike between tt and t
	for i=idx, pattern_idvec_.size-1 {
		if (pattern_tvec_.x[i] > t) { break }
		m = pattern_idvec_.x[i]
		if (m < num_mitral + num_granule) {
			glys(m)
		}
	}
	idx = i+1
	sc_.g.flush()
}

Loading data, please wait...