Synchrony by synapse location (McTavish et al. 2012)

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Accession:144054
This model considers synchrony between mitral cells induced via shared granule cell interneurons while taking into account the spatial constraints of the system. In particular, since inhibitory inputs decay passively along the lateral dendrites, this model demonstrates that an optimal arrangement of the inhibitory synapses will be near the cell bodies of the relevant mitral cells.
Reference:
1 . McTavish TS, Migliore M, Shepherd GM, Hines ML (2012) Mitral cell spike synchrony modulated by dendrodendritic synapse location. Front Comput Neurosci 6:3 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Synchronization; Olfaction;
Implementer(s): McTavish, Thomas S [thomas.mctavish at yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell; GabaB; AMPA; NMDA; I Na,t; I A; I K;
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mctavish_syncbylocation
src
ampanmda.mod
fi.mod
kamt.mod
kdrmt.mod
naxn.mod
ThreshDetect.mod *
allsynhinton.hoc *
analysis.py
animtest.py
antest.ses *
bulbspikes.py
clear.hoc
connect.hoc
control.ses
default.hoc
granule.hoc *
hinton.hoc
init.hoc *
iterator.hoc *
lptiter.hoc
mgrs.hoc
michele_movie.hoc
mitral.hoc
mosinit.hoc
net.hoc
param.hoc
params.py
parinit.hoc
pattern.hoc
perfrun.hoc
show.hoc
showw.hoc
somesyn.hoc *
sortspike *
split.hoc
start.hoc
start.ses
stimodors.hoc
subset.hoc
subset_control.ses *
synweightsnapshot.py
viewspikes.hoc
viewspikes1.hoc
weight_movie.hoc
weightsave.hoc
                            
if (!name_declared("is_split")) {execute("is_split = 0")}

splitbit = 6e8
func basegid() {
	// from piece gid, return base gid
	return $1 % splitbit
}
func piecegid() {
	// from base gid return -1 if no piece on this cpu, otherwise
	// the piece gid
	// note that if several pieces of a mitral cell exist on this
	// cpu, then the smallest gid is returned
	if (pc.gid_exists($1)) {
		return $1
	}else if (pc.gid_exists($1 + splitbit)) {
		return $1 + splitbit
	}else if (pc.gid_exists($1 + 2*splitbit)) {
		return $1 + 2*splitbit
	}else{
		return -1
	}
}
obfunc gid2piece() {local sgid  localobj nil
	// from base gid return nil if no piece, otherwise
	// the cell piece object
	// note that a cell object may contain 1, 2, or 3 mitral pieces
	sgid = piecegid($1)
	if (sgid >= 0) {
		return pc.gid2cell(sgid)
	}else{
		return nil
	}
}

func exists() {localobj cell
	cell = gid2piece($1)
	if (object_id(cell)) if (section_exists($s2, cell)) {
		return 1
	}
	return 0
}

// split a mitral cell ($1 gid, $o2 whole cell) into three pieces
// destroy the pieces not on this cpu
// and connect pieces with multisplit
// arg is the base gid
proc splitmitral() {localobj cell, sl, nil
	if ($1 >= num_mitral) return // it is a granule
	cell = $o2
	if (is_split == 0) {
		//cell.axon pc.cell($1, new NetCon(&v(1), nil), 1)
		cell.soma pc.cell($1, new NetCon(&v(.5), nil), 1)
		// do not split
		return
	}
	// split
	cell.secden[0] disconnect()
	cell.secden[1] disconnect()
	// destroy what is not supposed to exist on this cpu
	if (!pc.gid_exists($1 + splitbit)) {
		cell.secden[0] delete_section()
	}
	if (!pc.gid_exists($1 + 2*splitbit)) {
		cell.secden[1] delete_section()
	}
	if (!pc.gid_exists($1)) {
		sl = new SectionList()
		cell.soma sl.wholetree()
		forsec sl {
			delete_section()
		}
	}
	// multisplit connect using the base gid
	// also associate the split gids with the cell object
	if (pc.gid_exists($1))cell.soma {
		pc.multisplit(.5, $1)
		//cell.axon pc.cell($1, new NetCon(&v(1), nil), 1)
		pc.cell($1, new NetCon(&v(.5), nil), 1)
	}
	if (pc.gid_exists($1 + splitbit)) cell.secden[0] {
		pc.multisplit(0, $1)
		pc.cell($1 + splitbit, new NetCon(&v(.5), nil), 0)
	}
	if (pc.gid_exists($1 + 2*splitbit)) cell.secden[1] {
		pc.multisplit(0, $1)
		pc.cell($1 + 2*splitbit, new NetCon(&v(.5), nil), 0)
	}
}

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