Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)

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Accession:144089
"... Here, we use a compartmental modeling approach to search for discriminatory features in the properties of incoming stimuli to a PFC pyramidal neuron and/or its response that signal which of these stimuli will result in persistent activity emergence. Furthermore, we use our modeling approach to study cell-type specific differences in persistent activity properties, via implementing a regular spiking (RS) and an intrinsic bursting (IB) model neuron. ... Collectively, our results pinpoint to specific features of the neuronal response to a given stimulus that code for its ability to induce persistent activity and predict differential roles of RS and IB neurons in persistent activity expression. "
Reference:
1 . Sidiropoulou K, Poirazi P (2012) Predictive Features of Persistent Activity Emergence in Regular Spiking and Intrinsic Bursting Model Neurons Plos Computational Biology 8(4):e1002489 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex layer 5-6 pyramidal cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA; IP3;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Detailed Neuronal Models;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr];
Search NeuronDB for information about:  Neocortex layer 5-6 pyramidal cell; GabaA; GabaB; AMPA; NMDA; IP3; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN; Gaba; Glutamate;

Sidiropoulou K, Poirazi P (2012) Predictive Features of Persistent Activity Emergence in Regular Spiking and Intrinsic Bursting Model Neurons Plos Computational Biology 8(4):e1002489[PubMed]

References and models cited by this paper

References and models that cite this paper

Amit DJ (1995) The Hebbian paradigm reintegrated: Local reverberations as internal representation Behav Brain Sci 18:617-657

Ariav G, Polsky A, Schiller J (2003) Submillisecond precision of the input-output transformation function mediated by fast sodium dendritic spikes in basal dendrites of CA1 pyramidal neurons. J Neurosci 23:7750-8 [PubMed]

Arsiero M, Luscher HR, Lundstrom BN, Giugliano M (2007) The Impact of Input Fluctuations on the Frequency-Current Relationships of Layer 5 Pyramidal Neurons in the Rat Medial Prefrontal Cortex. J Neurosci 27(12):3274-3284 [Journal] [PubMed]

   Input Fluctuations effects on f-I curves (Arsiero et al. 2007) [Model]

Balleine BW, Leung BK, Ostlund SB (2011) The orbitofrontal cortex, predicted value, and choice. Ann N Y Acad Sci 1239:43-50

Berger T, Luscher HR, Giugliano M (2006) Transient rhythmic network activity in the somatosensory cortex evoked by distributed input in vitro. Neuroscience 140:1401-13 [PubMed]

Bergstrom HC, McDonald CG, French HT, Smith RF (2008) Continuous nicotine administration produces selective, age-dependent structural alteration of pyramidal neurons from prelimbic cortex. Synapse 62:31-9 [PubMed]

   [111 reconstructed morphologies on NeuroMorpho.Org]

Branco T, Hausser M (2011) Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron 69:885-92 [Journal] [PubMed]

   Dendritic Discrimination of Temporal Input Sequences (Branco et al. 2010) [Model]

Chang YM, Luebke JI (2007) Electrophysiological diversity of layer 5 pyramidal cells in the prefrontal cortex of the rhesus monkey: in vitro slice studies. J Neurophysiol 98:2622-32 [PubMed]

Compte A, Constantinidis C, Tegner J, Raghavachari S, Chafee MV, Goldman-Rakic PS, Wang XJ (2003) Temporally irregular mnemonic persistent activity in prefrontal neurons of monkeys during a delayed response task. J Neurophysiol 90:3441-54 [Journal] [PubMed]

Connors BW, Gutnick MJ (1990) Intrinsic firing patterns of diverse neocortical neurons. Trends Neurosci 13:99-104 [PubMed]

de Polavieja GG, Harsch A, Kleppe I, Robinson HP, Juusola M (2005) Stimulus history reliably shapes action potential waveforms of cortical neurons. J Neurosci 25:5657-65

Degenetais E, Thierry AM, Glowinski J, Gioanni Y (2002) Electrophysiological properties of pyramidal neurons in the rat prefrontal cortex: an in vivo intracellular recording study. Cereb Cortex 12:1-16 [PubMed]

Dembrow NC, Chitwood RA, Johnston D (2010) Projection-specific neuromodulation of medial prefrontal cortex neurons. J Neurosci 30:16922-37 [PubMed]

Destexhe A, Mainen ZF, Sejnowski TJ (1994) Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism. J Comput Neurosci 1:195-230 [Journal] [PubMed]

   Application of a common kinetic formalism for synaptic models (Destexhe et al 1994) [Model]
   Kinetic synaptic models applicable to building networks (Destexhe et al 1998) [Model]

Dombeck DA, Harvey CD, Tian L, Looger LL, Tank DW (2010) Functional imaging of hippocampal place cells at cellular resolution during virtual navigation. Nat Neurosci 13:1433-40 [PubMed]

Dong Y, Cooper D, Nasif F, Hu XT, White FJ (2004) Dopamine modulates inwardly rectifying potassium currents in medial prefrontal cortex pyramidal neurons. J Neurosci 24:3077-85 [PubMed]

Dong Y, White FJ (2003) Dopamine D1-class receptors selectively modulate a slowly inactivating potassium current in rat medial prefrontal cortex pyramidal neurons. J Neurosci 23:2686-95 [PubMed]

Durstewitz D, Gabriel T (2006) Dynamical Basis of Irregular Spiking in NMDA-Driven Prefrontal Cortex Neurons Cereb Cortex 17:894-908 [Journal] [PubMed]

   Irregular spiking in NMDA-driven prefrontal cortex neurons (Durstewitz and Gabriel 2006) [Model]

Egorov AV, Hamam BN, Fransen E, Hasselmo ME, Alonso AA (2002) Graded persistent activity in entorhinal cortex neurons. Nature 420:173-8 [PubMed]

Epsztein J, Brecht M, Lee AK (2011) Intracellular determinants of hippocampal CA1 place and silent cell activity in a novel environment. Neuron 70:109-20 [PubMed]

Fowler MA, Sidiropoulou K, Ozkan ED, Phillips CW, Cooper DC (2007) Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. PLoS One 2:e573-210 [PubMed]

Fox RF (1997) Stochastic versions of the Hodgkin-Huxley equations. Biophys J 72:2068-74 [PubMed]

Fransen E, Tahvildari B, Egorov AV, Hasselmo ME, Alonso AA (2006) Mechanism of graded persistent cellular activity of entorhinal cortex layer v neurons. Neuron 49:735-46 [PubMed]

Funahashi S, Bruce CJ, Goldman-Rakic PS (1989) Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol 61:331-49 [Journal] [PubMed]

Goldman-Rakic PS (1995) Cellular basis of working memory. Neuron 14:477-85 [PubMed]

Goldman-Rakic PS (1996) Regional and cellular fractionation of working memory. Proc Natl Acad Sci U S A 93:13473-80 [PubMed]

Gollisch T, Meister M (2008) Rapid neural coding in the retina with relative spike latencies. Science 319:1108-11 [PubMed]

Gomez Gonzalez JF, Mel BW, Poirazi P (2012) Distinguishing Linear vs. Non-Linear Integration in CA1 Radial Oblique Dendrites: It's about Time. Front Comput Neurosci. [Journal] [PubMed]

   Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011) [Model]

Gorelova NA, Yang CR (2000) Dopamine D1-D5 receptor activation modulates a persistent sodium current in rat prefrontal cortical neurons in vitro. J Neurophysiol 84:75-87 [Journal] [PubMed]

Greene CC, Schwindt PC, Crill WE (1994) Properties and ionic mechanisms of a metabotropic glutamate receptor-mediated slow afterdepolarization in neocortical neurons. J Neurophysiol 72:693-704 [PubMed]

Haj-Dahmane S, Andrade R (1998) Ionic mechanism of the slow afterdepolarization induced by muscarinic receptor activation in rat prefrontal cortex. J Neurophysiol 80:1197-210 [PubMed]

Haj-Dahmane S, Andrade R (1999) Muscarinic receptors regulate two different calcium-dependent non-selective cation currents in rat prefrontal cortex. Eur J Neurosci 11:1973-80 [PubMed]

Hasselmo ME, Stern CE (2006) Mechanisms underlying working memory for novel information. Trends Cogn Sci 10:487-93 [PubMed]

Hattox AM, Nelson SB (2007) Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties. J Neurophysiol 98:3330-40 [PubMed]

Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]

Hubel DH, Wiesel TN (1968) Receptive fields and functional architecture of monkey striate cortex. J Physiol 195:215-43 [PubMed]

Kim Y, Spruston N (2012) Target-specific output patterns are predicted by the distribution of regular-spiking and bursting pyramidal neurons in the subiculum. Hippocampus 22:693-706 [PubMed]

Kroener S, Chandler LJ, Phillips PE, Seamans JK (2009) Dopamine modulates persistent synaptic activity and enhances the signal-to-noise ratio in the prefrontal cortex. PLoS One 4:e6507-601 [PubMed]

Kubota K, Niki H (1971) Prefrontal cortical unit activity and delayed alternation performance in monkeys. J Neurophysiol 34:337-47 [Journal] [PubMed]

Linaro D, Storace M, Giugliano M (2011) Accurate and fast simulation of channel noise in conductance-based model neurons by diffusion approximation PLOS 7:e1001102 [Journal] [PubMed]

   Accurate and fast simulation of channel noise in conductance-based model neurons (Linaro et al 2011) [Model]

Lisman JE, Fellous JM, Wang XJ (1998) A role for NMDA-receptor channels in working memory. Nat Neurosci 1:273-5 [PubMed]

Lisman JE, Idiart MA (1995) Storage of 7 +/- 2 short-term memories in oscillatory subcycles. Science 267:1512-5 [PubMed]

Mann EO, Kohl MM, Paulsen O (2009) Distinct roles of GABA(A) and GABA(B) receptors in balancing and terminating persistent cortical activity. J Neurosci 29:7513-8 [PubMed]

Markram H, Lubke J, Frotscher M, Roth A, Sakmann B (1997) Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. J Physiol 500 ( Pt 2):409-40 [PubMed]

Maurice N, Tkatch T, Meisler M, Sprunger LK, Surmeier DJ (2001) D1-D5 dopamine receptor activation differentially modulates rapidly inactivating and persistent sodium currents in prefrontal cortex pyramidal neurons. J Neurosci 21:2268-77 [PubMed]

McCormick DA, Shu Y, Hasenstaub A, Sanchez-Vives M, Badoual M, Bal T (2003) Persistent cortical activity: mechanisms of generation and effects on neuronal excitability. Cereb Cortex 13:1219-31 [PubMed]

Merchant H, Crowe DA, Robertson MS, Fortes AF, Georgopoulos AP (2011) Top-down spatial categorization signal from prefrontal to posterior parietal cortex in the primate. Front Syst Neurosci 5:69-71 [PubMed]

Middlebrooks JC, Clock AE, Xu L, Green DM (1994) A panoramic code for sound location by cortical neurons. Science 264:842-4 [PubMed]

Miller EK, Cohen JD (2001) An integrative theory of prefrontal cortex function. Annu Rev Neurosci 24:167-202 [PubMed]

Milojkovic BA, Zhou WL, Antic SD (2007) Voltage and calcium transients in basal dendrites of the rat prefrontal cortex. J Physiol 585:447-68 [PubMed]

Morishima M, Kawaguchi Y (2006) Recurrent connection patterns of corticostriatal pyramidal cells in frontal cortex. J Neurosci 26:4394-405 [PubMed]

Nasif FJ, Sidiropoulou K, Hu XT, White FJ (2005) Repeated cocaine administration increases membrane excitability of pyramidal neurons in the rat medial prefrontal cortex. J Pharmacol Exp Ther 312:1305-13 [PubMed]

Nevian T, Larkum ME, Polsky A, Schiller J (2007) Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study. Nat Neurosci 10:206-14 [Journal] [PubMed]

   Dendritic Na+ spike initiation and backpropagation of APs in active dendrites (Nevian et al. 2007) [Model]

O'Keefe J (1976) Place units in the hippocampus of the freely moving rat. Exp Neurol 51:78-109 [PubMed]

Otsuka T, Kawaguchi Y (2008) Firing-pattern-dependent specificity of cortical excitatory feed-forward subnetworks. J Neurosci 28:11186-95 [PubMed]

Pissadaki EK, Sidiropoulou K, Reczko M, Poirazi P (2010) Encoding of spatio-temporal input characteristics by a CA1 pyramidal neuron model. PLoS Comput Biol 6:e1001038 [PubMed]

Poirazi P, Brannon T, Mel BW (2003a) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37:977-987 [Journal] [PubMed]

   CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003) [Model]

Polsky A, Mel B, Schiller J (2009) Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. J Neurosci 29:11891-903 [Journal] [PubMed]

   NMDA spikes in basal dendrites of L5 pyramidal neurons (Polsky et al. 2009) [Model]

Priebe NJ, Ferster D (2008) Inhibition, spike threshold, and stimulus selectivity in primary visual cortex. Neuron 57:482-97 [PubMed]

Rainer G, Asaad WF, Miller EK (1998) Memory fields of neurons in the primate prefrontal cortex. Proc Natl Acad Sci U S A 95:15008-13 [PubMed]

Rao SG, Williams GV, Goldman-Rakic PS (2000) Destruction and creation of spatial tuning by disinhibition: GABA(A) blockade of prefrontal cortical neurons engaged by working memory. J Neurosci 20:485-94 [PubMed]

Rathbun DL, Alitto HJ, Weyand TG, Usrey WM (2007) Interspike interval analysis of retinal ganglion cell receptive fields. J Neurophysiol 98:911-9 [PubMed]

Reich DS, Mechler F, Purpura KP, Victor JD (2000) Interspike intervals, receptive fields, and information encoding in primary visual cortex. J Neurosci 20:1964-74 [PubMed]

Sasaki T, Matsuki N, Ikegaya Y (2011) Action-potential modulation during axonal conduction. Science 331:599-601 [PubMed]

Seamans JK, Durstewitz D, Christie BR, Stevens CF, Sejnowski TJ (2001) Dopamine D1-D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons. Proc Natl Acad Sci U S A 98:301-6 [PubMed]

Seamans JK, Nogueira L, Lavin A (2003) Synaptic basis of persistent activity in prefrontal cortex in vivo and in organotypic cultures. Cereb Cortex 13:1242-50 [PubMed]

Shu Y, Hasenstaub A, McCormick DA (2003) Turning on and off recurrent balanced cortical activity. Nature 423:288-93 [PubMed]

Sidiropoulou K, Lu FM, Fowler MA, Xiao R, Phillips C, Ozkan ED, Zhu MX, White FJ, Cooper DC (2009) Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity. Nat Neurosci 12:190-9 [PubMed]

Spalthoff C, Egelhaaf M, Tinnefeld P, Kurtz R (2010) Localized direction selective responses in the dendrites of visual interneurons of the fly. BMC Biol 8:36-501 [PubMed]

Stewart A, Foehring RC (2000) Calcium currents in retrogradely labeled pyramidal cells from rat sensorimotor cortex. J Neurophysiol 83:2349-54 [PubMed]

Tamas G, Buhl EH, Somogyi P (1997) Fast IPSPs elicited via multiple synaptic release sites by different types of GABAergic neurone in the cat visual cortex. J Physiol 500 ( Pt 3):715-38 [PubMed]

Tegner J, Compte A, Wang XJ (2002) The dynamical stability of reverberatory neural circuits. Biol Cybern 87:471-81 [PubMed]

Tseng KY, O'Donnell P (2005) Post-pubertal emergence of prefrontal cortical up states induced by D1-NMDA co-activation. Cereb Cortex 15:49-57 [PubMed]

Tziridis K, Dicke PW, Thier P (2009) The role of the monkey dorsal pontine nuclei in goal-directed eye and hand movements. J Neurosci 29:6154-66 [PubMed]

Usher M, Cohen JD, Servan-Schreiber D, Rajkowski J, Aston-Jones G (1999) The role of locus coeruleus in the regulation of cognitive performance. Science 283:549-54 [PubMed]

Wang H, Stradtman GG, Wang XJ, Gao WJ (2008) A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex. Proc Natl Acad Sci U S A 105:16791-6 [PubMed]

Wang J, O'Donnell P (2001) D(1) dopamine receptors potentiate nmda-mediated excitability increase in layer V prefrontal cortical pyramidal neurons. Cereb Cortex 11:452-62 [PubMed]

Wang XJ (1999) Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory. J Neurosci 19:9587-603 [PubMed]

Wang XJ (2001) Synaptic reverberation underlying mnemonic persistent activity. Trends Neurosci 24:455-63 [PubMed]

Wang XJ (2002) Probabilistic decision making by slow reverberation in cortical circuits. Neuron 36:955-68 [PubMed]

Wilson FA, O'Scalaidhe SP, Goldman-Rakic PS (1994) Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex. Proc Natl Acad Sci U S A 91:4009-13 [PubMed]

Yamada M, Pita MC, Iijima T, Tsutsui K (2010) Rule-dependent anticipatory activity in prefrontal neurons. Neurosci Res 67:162-71 [PubMed]

Yang CR, Seamans JK (1996) Dopamine D1 receptor actions in layers V-VI rat prefrontal cortex neurons in vitro: modulation of dendritic-somatic signal integration. J Neurosci 16:1922-35 [PubMed]

Yang CR, Seamans JK, Gorelova N (1996) Electrophysiological and morphological properties of layers V-VI principal pyramidal cells in rat prefrontal cortex in vitro. J Neurosci 16:1904-21 [PubMed]

Yoshida M, Fransen E, Hasselmo ME (2008) mGluR-dependent persistent firing in entorhinal cortex layer III neurons. Eur J Neurosci 28:1116-26 [PubMed]

Yoshida M, Hasselmo ME (2009) Persistent firing supported by an intrinsic cellular mechanism in a component of the head direction system. J Neurosci 29:4945-52 [PubMed]

Young CE, Yang CR (2004) Dopamine D1-D5 receptor modulates state-dependent switching of soma-dendritic Ca2+ potentials via differential protein kinase A and C activation in rat prefrontal cortical neurons. J Neurosci 24:8-23 [PubMed]

Yuen EY, Jiang Q, Chen P, Feng J, Yan Z (2008) Activation of 5-HT2A-C receptors counteracts 5-HT1A regulation of n-methyl-D-aspartate receptor channels in pyramidal neurons of prefrontal cortex. J Biol Chem 283:17194-204 [PubMed]

Yuen EY, Jiang Q, Chen P, Gu Z, Feng J, Yan Z (2005) Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism. J Neurosci 25:5488-501 [PubMed]

Behabadi BF, Mel BW (2014) Mechanisms underlying subunit independence in pyramidal neuron dendrites. Proc Natl Acad Sci U S A 111:498-503 [Journal] [PubMed]

   Mechanisms underlying subunit independence in pyramidal neuron dendrites (Behabadi and Mel 2014) [Model]

Neymotin SA, McDougal RA, Bulanova AS, Zeki M, Lakatos P, Terman D, Hines ML, Lytton WW (2016) Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex Neuroscience 316:344-366 [Journal] [PubMed]

   Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016) [Model]

Papoutsi A, Sidiropoulou K, Cutsuridis V, Poirazi P (2013) Induction and modulation of persistent activity in a layer V PFC microcircuit model. Front Neural Circuits 7:161 [Journal] [PubMed]

   L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013) [Model]

Papoutsi A, Sidiropoulou K, Poirazi P (2014) Dendritic nonlinearities reduce network size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model PLoS Computational Biology 10(7):e1003764 [Journal] [PubMed]

   L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013) [Model]

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