Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)

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Accession:144089
"... Here, we use a compartmental modeling approach to search for discriminatory features in the properties of incoming stimuli to a PFC pyramidal neuron and/or its response that signal which of these stimuli will result in persistent activity emergence. Furthermore, we use our modeling approach to study cell-type specific differences in persistent activity properties, via implementing a regular spiking (RS) and an intrinsic bursting (IB) model neuron. ... Collectively, our results pinpoint to specific features of the neuronal response to a given stimulus that code for its ability to induce persistent activity and predict differential roles of RS and IB neurons in persistent activity expression. "
Reference:
1 . Sidiropoulou K, Poirazi P (2012) Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons. PLoS Comput Biol 8:e1002489 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA; IP3;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Detailed Neuronal Models;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic GLU cell; GabaA; GabaB; AMPA; NMDA; IP3; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN; Gaba; Glutamate;
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PFCcell
lib
basic-graphics.hoc *
choose-secs.hoc
current-balance.hoc
cut-sections.hoc *
distance.hoc
ken.h *
map-segments-to-3d.hoc *
mod_func.c *
newshiftsyn *
newshiftsyn.c *
num-rec.h *
salloc.hoc
vector-distance.hoc *
verbose-system.hoc *
                            
// This function is used to balance the membrane potential to v_init (= -70 mV)
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

proc current_balance() {
	
  finitialize($1)
  fcurrent()	
  printf("Balancing each compartment to %d mV\n", $1)

  forall {
    for (x) {
    	if (ismembrane("na_ion")) {e_pas(x)=v(x)+ina(x)/g_pas(x)} 
   	if (ismembrane("k_ion")) {e_pas(x)=e_pas(x)+ik(x)/g_pas(x)} 
    	if (ismembrane("ca_ion")) {e_pas(x)=e_pas(x)+ica(x)/g_pas(x)}
       // if (ismembrane("Ca_ion")) {e_pas(x)=e_pas(x)+iCa(x)/g_pas(x)}
        if (ismembrane("in_ion")) {e_pas(x)=e_pas(x)+in(x)/g_pas(x)} //ican
       if (ismembrane("h")) {e_pas(x)=e_pas(x)+ihi(x)/g_pas(x)}

       
        //d = distance(1,x)
	//xdist = find_vector_distance_precise(secname(),x)    // calc. perpedicular distance      
	//printf("x = %e, xdist = %e, d = %e, e_pas = %e mV, rm = %e mA/(mVcm2)\n", x,  xdist, d, e_pas(x), 1./g_pas(x))
      	
	fcurrent()
    }
 
}

finitialize(v_init)
fcurrent()
        if (cvode.active()) {
        cvode.re_init()
        }       else {
        fcurrent()
        }
frecord_init()

}

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