Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)

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Accession:144089
"... Here, we use a compartmental modeling approach to search for discriminatory features in the properties of incoming stimuli to a PFC pyramidal neuron and/or its response that signal which of these stimuli will result in persistent activity emergence. Furthermore, we use our modeling approach to study cell-type specific differences in persistent activity properties, via implementing a regular spiking (RS) and an intrinsic bursting (IB) model neuron. ... Collectively, our results pinpoint to specific features of the neuronal response to a given stimulus that code for its ability to induce persistent activity and predict differential roles of RS and IB neurons in persistent activity expression. "
Reference:
1 . Sidiropoulou K, Poirazi P (2012) Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons. PLoS Comput Biol 8:e1002489 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA; IP3;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Detailed Neuronal Models;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; GabaA; GabaB; AMPA; NMDA; IP3; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN; Gaba; Glutamate;
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PFCcell
mechanism
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.directory
                            
:Taken form Durstewitz et al, 2002
: Slowly inactivating K+ channel


NEURON {
	SUFFIX Ks
	USEION k READ ek WRITE ik
	RANGE gKsbar, ik, gk
	
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
        (mM) = (milli/liter)
	
}
INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}
PARAMETER {
	v (mV)
	dt (ms)
	gKsbar	:= 0.00014 (mho/cm2) <0,1e9>
	
}


STATE {
	a b
}


ASSIGNED {
	ik (mA/cm2)
	ainf binf
	atau (ms)
	btau (ms)
	gk (mho/cm2)
	ek  (mV)
	:ki (mM)
	:ko  (mM)
}



INITIAL {
	rate(v)
	a = ainf
	b = binf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
		
	gk = gKsbar * a * b
	:ek = 25 * log(ko/ki)
	ik = gk*(v-ek)
	
}

DERIVATIVE states {
	rate(v)
	
	a' = (ainf-a)/atau
	b' = (binf-b)/btau
}
UNITSOFF

PROCEDURE rate(v (mV)) {LOCAL va, vb, vc, vd
	
	
	va = v + 34
	vb = v + 65
	vd = v + 63.6
	

if (fabs(va)<1e-04){ va = va+0.00001 }
	   ainf = 1/(1 + exp(-va/6.5))
	   atau=10 
	   :atau = 10
	   :atau = 6

	

if (fabs(vb)<1e-04){ vb = vb+0.00001 }
	   binf = 1/(1 + exp(vb/6.6))

 
if (fabs(vd)<1e-04){ vd = vd+0.00001 }
	btau = 3400	:based on dong and white,2003   
	:btau = 200 + 3200 / (1 + exp(-vd/4))

}

	
UNITSON








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