Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)

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Accession:144089
"... Here, we use a compartmental modeling approach to search for discriminatory features in the properties of incoming stimuli to a PFC pyramidal neuron and/or its response that signal which of these stimuli will result in persistent activity emergence. Furthermore, we use our modeling approach to study cell-type specific differences in persistent activity properties, via implementing a regular spiking (RS) and an intrinsic bursting (IB) model neuron. ... Collectively, our results pinpoint to specific features of the neuronal response to a given stimulus that code for its ability to induce persistent activity and predict differential roles of RS and IB neurons in persistent activity expression. "
Reference:
1 . Sidiropoulou K, Poirazi P (2012) Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons. PLoS Comput Biol 8:e1002489 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA; IP3;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Detailed Neuronal Models;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; GabaA; GabaB; AMPA; NMDA; IP3; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN; Gaba; Glutamate;
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PFCcell
mechanism
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netstimmm.mod
NMDA.mod
sinclamp.mod
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COMMENT
Since this is an electrode current, positive values of i depolarize the cell
and in the presence of the extracellular mechanism there will be a change
in vext since i is not a transmembrane current but a current injected
directly to the inside of the cell.
ENDCOMMENT

NEURON {
        POINT_PROCESS SinClamp
        RANGE del, dur, pkamp, freq, phase, bias
        ELECTRODE_CURRENT i
}

UNITS {
        (nA) = (nanoamp)
             }

PARAMETER {
        del=0   (ms)
        dur=200   (ms)
        pkamp=0.5 (nA) :1
        freq=1  (Hz)
        phase=0 (rad)
        bias=0  (nA)
        PI=3.14159265358979323846
}

ASSIGNED {
        i (nA)
}

BREAKPOINT {
       if (t < del) {
      i=0   
   }else{ 
            if (t < del+dur) {
           i = pkamp*sin(2*PI*freq*(t-del)/1000+phase)+bias
      }else{ 
           i = 0
}}} 

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