Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:144089
"... Here, we use a compartmental modeling approach to search for discriminatory features in the properties of incoming stimuli to a PFC pyramidal neuron and/or its response that signal which of these stimuli will result in persistent activity emergence. Furthermore, we use our modeling approach to study cell-type specific differences in persistent activity properties, via implementing a regular spiking (RS) and an intrinsic bursting (IB) model neuron. ... Collectively, our results pinpoint to specific features of the neuronal response to a given stimulus that code for its ability to induce persistent activity and predict differential roles of RS and IB neurons in persistent activity expression. "
Reference:
1 . Sidiropoulou K, Poirazi P (2012) Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons. PLoS Comput Biol 8:e1002489 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA; IP3;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Detailed Neuronal Models;
Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; GabaA; GabaB; AMPA; NMDA; IP3; I Na,p; I Na,t; I L high threshold; I A; I K; I K,Ca; I CAN; Gaba; Glutamate;
/
PFCcell
mechanism
.AppleDouble
ampa.mod
cad.mod
cal.mod
can.mod *
car.mod *
cat.mod *
d3.mod *
gabaa.mod *
gabab.mod *
h.mod
ican.mod
kadist.mod *
kca.mod *
kct.mod *
kd.mod
kdrD.mod *
km.mod *
naf.mod
nap.mod *
netstimmm.mod
NMDA.mod
sinclamp.mod
.directory
                            
TITLE Kct current

COMMENT Equations from 
		  Shao L.R., Halvorsrud R., Borg-Graham L., Storm J.F. The role of BK-type Ca2_-dependent K+ channels in spike broadening during repetitive firing in rat hippocampal pyramidal cells J.Physiology (1999),521:135-146 
		  
		  The Krasnow Institute
		  George Mason University

Copyright	  Maciej Lazarewicz, 2001
		  (mlazarew@gmu.edu)
		  All rights reserved.
ENDCOMMENT

NEURON {
	SUFFIX  mykca
	USEION k READ ek WRITE ik
	USEION ca READ cai   
	RANGE  gkbar,ik
}

UNITS {
	(molar) = (1/liter)
	(mM)	= (millimolar)
	(S)  	= (siemens)
	(mA) 	= (milliamp)
	(mV) 	= (millivolt)
}

PARAMETER {
        gkbar	= 0	 (S/cm2)
	:gkbar	= 1.0e-3 (S/cm2)
}

ASSIGNED {
        v       (mV)
        cai	(mM)     :26/10/04   htan se sxolio
	celsius		 (degC)
	ek		(mV)
	ik	(mA/cm2)
	k1	(/ms)
	k2	(/ms)
	k3	(/ms)
	k4	(/ms)
	q10	(1)
}

STATE { cst ost ist }

BREAKPOINT { 
	SOLVE kin METHOD sparse
	ik = gkbar * ost *( v - ek ) 
}

INITIAL {
	SOLVE kin STEADYSTATE sparse
}

KINETIC kin {
:	rates(v, cani)
	rates(v, cai)
	~cst<->ost  (k3,k4)
	~ost<->ist  (k1,0.0)
	~ist<->cst  (k2,0.0)
	CONSERVE cst+ost+ist=1
}

:change feb8th for pfc
:PROCEDURE rates( v(mV), cani(mM)) {
PROCEDURE rates( v(mV), cai(mM)) {
:	 k1=alp( 0.1, v,  -10.0,   1.0 ) : original
	 k1=alp( 0.1, v,  -10.0,   1.0 ) :increases the current
	 k2=alp( 0.1, v, -120.0, -10.0 ) :original (0.1, -120, -10)
:	 k3=alpha( 0.001, 1.0, v, -20.0, 7.0 ) *1.0e8* ( cai*1.0(/mM) )^3  :original
	 k3=alpha( 0.001, 1.0, v, -20.0, 7.0 ) *1.0e8* (cai*1.0(/mM) )^2
	 :k3 changes the attenuation
	 k4=alp( 0.01, v, -44.0,  -5.0 ) :original
:	 k4=alp( 0.2, v, -44.0,  -5.0 )
}

FUNCTION alpha( tmin(ms), tmax(ms), v(mV), vhalf(mV), k(mV) )(/ms){
        alpha = 1.0 / ( tmin + 1.0 / ( 1.0 / (tmax-tmin) + exp((v-vhalf)/k)*1.0(/ms) ) )
}

FUNCTION alp( tmin(ms), v(mV), vhalf(mV), k(mV) )(/ms){
        alp = 1.0 / ( tmin + exp( -(v-vhalf) / k )*1.0(ms) )
}










Loading data, please wait...