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Hodgkin-Huxley model of persistent activity in PFC neurons (Winograd et al. 2008) (NEURON python)
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Accession:
144376
The paper demonstrate a form of graded persistent activity activated by hyperpolarization. This phenomenon is modeled based on a slow calcium regulation of Ih, similar to that introduced earlier for thalamic neurons (see Destexhe et al., J Neurophysiol. 1996). The only difference is that the calcium signal is here provided by the high-threshold calcium current (instead of the low-threshold calcium current in thalamic neurons).
Reference:
1 .
Winograd M, Destexhe A, Sanchez-Vives MV (2008) Hyperpolarization-activated graded persistent activity in the prefrontal cortex.
Proc Natl Acad Sci U S A
105
:7298-303
[
PubMed
]
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Channel/Receptor;
Brain Region(s)/Organism:
Prefrontal cortex (PFC);
Cell Type(s):
Channel(s):
I Na,t;
I L high threshold;
I K;
I M;
I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
NEURON;
Model Concept(s):
Activity Patterns;
Ion Channel Kinetics;
Implementer(s):
Skolnick, Yosef [yskolnick at gmail.com];
Search NeuronDB
for information about:
I Na,t
;
I L high threshold
;
I K
;
I M
;
I h
;
/
Skolnik_python_WinogradEtAl2008
readme.txt
APCounter2.mod
*
Other models using APCounter2.mod:
Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)
Cadynamics.mod
*
Other models using Cadynamics.mod:
Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)
HH2.mod
*
Other models using HH2.mod:
Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)
ICaL.mod
*
Other models using ICaL.mod:
Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)
Ih.mod
*
Other models using Ih.mod:
Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)
IKM.mod
*
Other models using IKM.mod:
Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
Cortical feedback alters visual response properties of dLGN relay cells (Martínez-Cañada et al 2018)
Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)
Hodgkin-Huxley models of different classes of cortical neurons (Pospischil et al. 2008)
Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001)
ipulse3.mod
*
Other models using ipulse3.mod:
Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)
pasi.mod
*
Other models using pasi.mod:
Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)
demo_HPGA_non_saturating.py
demo_HPGA_non_saturating_noIh.py
demo_HPGA_saturating.py
geoms.py
pyinit.py
simgui.hoc
simgui.py
winograd.py
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HPGA non-saturating
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