This paper introduces a novel neuron model, where the cell volume is a time-varying variable and multiple physical principles are combined to build governing equations. Using this model, we analyzed neuronal volume responses during excitation, which elucidated the waveforms of fast intrinsic optical signals observed experimentally across the literature. In addition, we analyzed volume responses on a longer time scale with repetitive stimulation to study the characteristics of slow cell swelling.
Lee J, Boas DA, Kim SJ (2011) Multiphysics neuron model for cellular volume dynamics. IEEE Trans Biomed Eng 58:3000-3 [PubMed]