Dendro-dendritic synaptic circuit (Shepherd Brayton 1979)

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Accession:144385
A NEURON simulation has been created to model the passive spread of an EPSP from a mitral cell synapse on a granule cell spine. The EPSP was shown to propagate subthreshold through the dendritic shaft into an adjacent spine with significant amplitude (figure 2B).
Reference:
1 . Shepherd GM, Brayton RK (1979) Computer simulation of a dendrodendritic synaptic circuit for self- and lateral-inhibition in the olfactory bulb. Brain Res 175:377-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Influence of Dendritic Geometry; Olfaction;
Implementer(s): Morse, Tom [Tom.Morse at Yale.edu];
// init.hoc initiailze dendrite and spines simulation
// load the standard nrn libraries
load_file("nrngui.hoc")

// define the dendrite shape
load_file("hoc/gr_dendrite_morphology.hoc")

// load the Spine class and place spines on dendrite
// the below lists store sections when the Spine template is called
// these lists can be then used with forsec:
objref spine_list, spinehead_list, spineneck_list
spine_list = new SectionList()
spinehead_list=new SectionList()
spineneck_list=new SectionList()

load_file("hoc/spine_template.hoc")
load_file("hoc/spine_placement.hoc")

// create a "rig" to record and stimulate dendrite/spines
load_file("hoc/runcntrl_graphs_iclamp.ses")

//insert currents and receptors
load_file("hoc/electrotonic_length.hoc") // parameters to study electrotonic length

// load_file("calcium1.ses") // display a graph of cai in spine head
load_file("hoc/v_soma_spine_dend.ses")

// loads the traces onto a couple of voltage graphs
load_file("hoc/traceX_reader.hoc")

// files for the Multiple Run Fitter
load_file("hoc/params.hoc")
load_file("mrf/mrf.ses")

// add on a couple extra compartments to extend the granule cell as per fig 1
load_file("hoc/extra_dendrite.hoc")



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