Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)

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Accession:144450
The hippocampus in well known for its role in learning and memory processes. The CA1 region is the output of the hippocampal formation and pyramidal neurons in this region are the elementary units responsible for the processing and transfer of information to the cortex. Using this detailed single neuron model, it is investigated the conditions under which individual CA1 pyramidal neurons process incoming information in a complex (non-linear) as opposed to a passive (linear) manner. This detailed compartmental model of a CA1 pyramidal neuron is based on one described previously (Poirazi, 2003). The model was adapted to five different reconstructed morphologies for this study, and slightly modified to fit the experimental data of (Losonczy, 2006), and to incorporate evidence in pyramidal neurons for the non-saturation of NMDA receptor-mediated conductances by single glutamate pulses. We first replicate the main findings of (Losonczy, 2006), including the very brief window for nonlinear integration using single-pulse stimuli. We then show that double-pulse stimuli increase a CA1 pyramidal neuron’s tolerance for input asynchrony by at last an order of magnitude. Therefore, it is shown using this model, that the time window for nonlinear integration is extended by more than an order of magnitude when inputs are short bursts as opposed to single spikes.
Reference:
1 . Gómez González JF, Mel BW, Poirazi P (2011) Distinguishing Linear vs. Non-Linear Integration in CA1 Radial Oblique Dendrites: It's about Time. Front Comput Neurosci 5:44 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,p; I CAN; I Sodium; I Calcium; I Potassium; I_AHP;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Synaptic Integration;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; NMDA; I Na,p; I CAN; I Sodium; I Calcium; I Potassium; I_AHP;
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CA1_Gomez_2011
template
BasalPath.hoc
EPSPTuning.hoc *
ExperimentControl.hoc
ObliquePath.hoc *
RangeRef.hoc *
SynapseBand.hoc *
                            
// This template creates the Basal Path lists, starting from the
// section attached to the soma and ending with the basal tip section 
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu
// modified for working with the new Oblique Sectionlists by Jose Gomez jfcgomez@ull.es
// I changed  the loop "forsec"


begintemplate BasalPath

public basal_dtrunk_to_tip, basal_trunk_section, root_basal

strdef sexec

objref basal_trunk_section
strdef basal_trunk_section_name

objref root_basal
strdef root_basal_name

objref basal_tip_section
strdef basal_tip_section_name

objref basal_path

proc init () {
  sec_count=0

  forsec $o1 {
	
	if(sec_count==0){
			basal_tip_section    = new SectionRef()
    			basal_tip_section_name=secname()		
	}

	sec_count+=1
  }
sec_count-=1
i=0
  forsec $o1{
	if (sec_count==i){
		distance(0,1)
		basal_trunk_section  = new SectionRef()
		basal_trunk_section_name=secname()
	}
	
	if ((sec_count-1)==i){
		root_basal    = new SectionRef()
       		root_basal_name=secname()
	
	}

	i+=1	

  }



  access root_basal.sec
  distance(0,0)
  access basal_tip_section.sec
  basal_dtrunk_to_tip=distance(1,1)

//printf("BasalPath basal_trunk_section: %s root_basal: %s basal_tip_section: %s distance between root_basal and basal_tip_section: %g\n", basal_trunk_section_name, root_basal_name, basal_tip_section_name, basal_dtrunk_to_tip)
}

endtemplate BasalPath

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