CA1 pyramidal neuron dendritic spine with plasticity (O`Donnell et al. 2011)

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Accession:144463
Biophysical model of a dendritic spine and adjacent dendrite with synapse. Model parameters adjusted to fit CA3-CA1 Shaffer collateral synapse data from literature. Model includes both electrical and Ca2+ dynamics, including AMPARs, NMDARs, 4 types of CaV channel, and leak conductance. Spine and synapse are plastic according to Ca2+ dependent rule. The aim of the model is to explore the effects of dendritic spine structural plasticity on the rules of synaptic plasticity.
Reference:
1 . O'Donnell C, Nolan MF, van Rossum MCW (2011) Dendritic spine dynamics regulate the long-term stability of synaptic plasticity. J Neurosci 31:16142-56 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s): Cav3.1 CACNA1G; Cav1.3 CACNA1D; Cav1.2 CACNA1C; Cav2.1 CACNA1A;
Transmitter(s): Glutamate;
Simulation Environment: MATLAB;
Model Concept(s): Synaptic Plasticity; Calcium dynamics;
Implementer(s): O`Donnell, Cian [cian AT salk.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; Glutamate;
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ODonelletal_spinemodel
readme.txt
spinemodel_fig6.m
spineodes.m
                            
Matlab files to generate figure 6 from O'Donnell et al, J Neurosci, 2011.

Code simulates 3-compartment model: dendritic spine head, dendritic
spine neck, and adjoining dendritic branch. Simulation includes both
electrical and Ca2+ dynamics. See O'Donnell et al paper Methods
section and Figure 6 for further details.

Included are two files:
- spinemodel_fig6.m specifies all model and simulation parameters, calls
  spineodes.m, solves differential equations using a Matlab ODE solver,
  and plots figures.
- spineodes.m specifies system ODEs for use by spinemodel_fig6.m.

To try a basic simulation, simply run spinemodel_fig6.m as is from Matlab.

To vary model parameters, simulation parameters or stimulation
protocol, open spinemodel_fig6.m and investigate. Parameters are
clearly notated.

Any queries or comments can be sent to cian@salk.edu.

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